Gene expressions and copy numbers associated with metastatic phenotypes of uterine cervical cancer

BMC Genomics

Table 2 Cox regression analysis of progression free survival

	Univariate analysis			Multivariate analysis
Covariate¹	p	Relative risk	95% CI	p	Relative risk	95% CI
Model containing clinical variables alone
Tumor volume	< 0.0001	1.01	1.01 – 1.02	< 0.0001	1.01	1.01 – 1.02
Number of pathological lymph nodes	0.015	1.3	1.1 – 1.7	0.24
Metastatic status	0.30	1.7	0.64 – 4.3	0.47
Model containing gene variables alone
Gene expressions
MRPL11	0.0001	5.6	2.3 – 14	0.001	4.9	1.9 – 13
PDK2	0.013	3.2	1.3 – 7.9	0.008	3.8	1.4 – 10
CKS2	0.026	2.7	1.1 – 6.6	0.30
TBX3	0.028	0.37	0.15 – 0.90	0.006	0.24	0.09 – 0.67
MRPS23	0.032	2.7	1.1 – 6.9	0.87
MSN	0.035	0.31	0.10 – 0.92	0.40
KLF3	0.035	0.37	0.15 – 0.93	0.47
LSM3²	0.058	2.7	0.97 – 7.4	0.30
Model containing clinical and gene variables
Tumor volume				< 0.0001	1.01	1.01 – 1.02
PDK2				0.013	3.3	1.3 – 8.3
MRPL11				0.26
TBX3				0.12

¹Categorized variables were used for the gene variables and metastatic status, whereas the linear form were used for tumor volume and number of pathological lymph nodes.
²LSM3 expression did not reach a p-value below 0.05 when categorized data were used, but is included among the prognostic genes since analysis based on log₂ratios showed a p-value of 0.044.

ISSN: 1471-2164