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Table 3 List of genes spotted twice on the microarray filter which evinced a significant change in their mRNA expression in TGFβ-treated T84 cells compared to T84 cells grown solely in collagen I gel (= TGFβ-treated vs. control).

From: Gene expression in TGFbeta-induced epithelial cell differentiation in a three-dimensional intestinal epithelial cell differentiation model

Gene ontology class Gene name GenBank no chromosomal location TGFβ-treated vs. control
     ratio SD ratio SD
A FDPS: farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) T66907
1q22 0.29↓ (±0.24) 0.57↓ (±0.45)
A GRP58: glucose regulated protein, 58 kD, R33030 15q15 0.56↓ (±0.12) 0.60↓ (±0.16)
C BAP1: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) H09065 3p21.31-p21.2 0.72↓ (±0.19) 0.68↓ (±0.17)
D DRAP1: DR1-associated protein 1 AA421977
11q13.3 0.53↓ (±0.22) 0.60↓ (±0.19)
D AEBP1: AE binding protein 1 AA490462
7p13 0.48↓ (±0.34) 0.60↓ (±0.32)
D ZNF161: zinc finger protein 161 AA232647 17q23.3 0.71↓ (±0.13) 0.75↓ (±0.11)
E IGF2: insulin-like growth factor 2 (somatomedin A) N54596 11p15.5 0.57↓ (±0.16) 0.63↓ (±0.17)
E MAST1: microtubule associated serine/threonine kinase 1 AA479623 19p13.2 0.51↓ (±0.18) 0.59↓ (±0.48)
E EGFR: epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) R35665
7p12 0.47↓ (±0.04) 0.75↓ (±0.13)
E EPHA1: ephrin receptor EphA1 N90246 7q34 0.66↓ (±0.10) 0.63↓ (±0.07)
E RNTRE: related to the N terminus of tre AA281057
10p13 0.78↓ (±0.25) 0.71↓ (±0.21)
E EFNB2: ephrin-B2 AA461424
13q33 0.77↓ (±0.20) 0.79↓ (±0.06)
F UBE2N: ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) AA490124 12q21.33 0.76↓ (±0.16) 0.79↓ (±0.17)
I ATP6V0A1: ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 AA427472 17q21 0.65↓ (±0.02) 0.62↓ (±0.08)
  1. Genes are sorted by functional classification. A: Cellular metabolism (GO:0044237), Metabolism (other than energy metabolism), C: Nucleic acid binding (GO:0003676), D: Transcription regulator activity (GO:0030528), E: Signal transducer activity (GO:0004871), Signal transduction (GO:0007165) and Cell communication (GO:0007154), F: Cellular macromolecule metabolism (GO:0044260), I: Transport (GO:0006810), Downward arrow indicates down-regulated mRNA expression, bold indicates genes that have significant alteration in gene expression. Ratio is mean value calculated from three separate microarray experiments; SD is the standard deviation between separate experiments.