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Table 2 Genes 1–50 of the 180-gene signature of EGFR TKI sensitivity

From: Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors

Probeset Gene Description p-value
205891_at ADORA2B adenosine A2b receptor 1.65347E-12
213434_at EPIM epimorphin 2.03526E-12
211475_s_at BAG1 BCL2-associated athanogene 1.2089E-11
201716_at SNX1 sorting nexin 1 1.3942E-11
219933_at GLRX2 glutaredoxin 2 2.82157E-11
204513_s_at ELMO1 engulfment and cell motility 1 2.92588E-11
203011_at IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 4.20475E-11
202743_at PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) 4.51605E-11
204491_at PDE4D Phosphodiesterase 4D, cAMP-specific 8.05036E-11
204000_at GNB5 guanine nucleotide binding protein (G protein), beta 5 8.7681E-11
204115_at GNG11 guanine nucleotide binding protein (G protein), gamma 11 1.02678E-10
218913_s_at GMIP GEM interacting protein 2.64411E-10
200994_at IPO7 importin 7 2.65447E-10
202286_s_at TACSTD2 tumor-associated calcium signal transducer 2 2.75325E-10
209035_at MDK midkine (neurite growth-promoting factor 2) 7.31553E-10
218995_s_at EDN1 endothelin 1 7.75626E-10
219855_at NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11 8.77697E-10
209678_s_at PRKCI protein kinase C, iota 1.04253E-09
202501_at MAPRE2 microtubule-associated protein, RP/EB family, member 2 2.31343E-09
212117_at RHOQ ras homolog gene family, member Q 3.22134E-09
206277_at P2RY2 purinergic receptor P2Y, G-protein coupled, 2 3.92313E-09
209295_at TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 4.33798E-09
205376_at INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.50987E-09
206722_s_at EDG4 endothelial differentiation, lysophosphatidic acid GPCR,4 7.96715E-09
205673_s_at ASB9 ankyrin repeat and SOCS box-containing 9 1.24878E-08
201471_s_at SQSTM1 sequestosome 1 1.34231E-08
204352_at TRAF5 TNF receptor-associated factor 5 1.46887E-08
206907_at TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.57771E-08
218150_at ARL5 ADP-ribosylation factor-like 5 2.04888E-08
205459_s_at NPAS2 neuronal PAS domain protein 2 2.22961E-08
205455_at MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 2.45512E-08
202641_at ARL3 ADP-ribosylation factor-like 3 2.78193E-08
201667_at GJA1 gap junction protein, alpha 1, 43kDa (connexin 43) 2.86113E-08
210512_s_at VEGF vascular endothelial growth factor 2.90316E-08
212104_s_at RBM9 RNA binding motif protein 9 5.42805E-08
200762_at DPYSL2 dihydropyrimidinase-like 2 5.43168E-08
221235_s_at TGFBRAP1 transforming growth factor, beta receptor associated protein 1 5.51367E-08
211302_s_at PDE4B phosphodiesterase 4B, cAMP-specific 5.51731E-08
205080_at RARB retinoic acid receptor, beta 7.03586E-08
202266_at TTRAP TRAF and TNF receptor associated protein 7.2889E-08
205240_at GPSM2 G-protein signalling modulator 2 (AGS3-like, C. elegans) 8.30858E-08
213798_s_at CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 8.61121E-08
221819_at RAB35 RAB35, member RAS oncogene family 8.9216E-08
207011_s_at PTK7 PTK7 protein tyrosine kinase 7 9.78716E-08
204255_s_at VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.1087E-07
208864_s_at TXN thioredoxin 1.34274E-07
209885_at RHOD ras homolog gene family, member D 1.50021E-07
201923_at PRDX4 peroxiredoxin 4 1.6148E-07
204392_at CAMK1 calcium/calmodulin-dependent protein kinase I 2.24378E-07
203269_at NSMAF neutral sphingomyelinase (N-SMase) activation associated factor 2.59238E-07
  1. * Genes 51–180 are included [see Additional File 3]