Figure 2

Island represented in mirror of UCSC Genome Browser. The early replication island chr12.389 is displayed as an annotation track in a mirror copy of the UCSC Genome Browser and is available at [29]. The cosmid clones that support this island, ERC2-43A12 and ERC3-39D2, are also shown below. This island overlaps a BAC clone, RP11-302B13, for which both replication timing [18, 19] and an open chromatin status [22] are available. The dark boxes indicate that this region was found to replicate early (timing ratio = 2.00) and to have an open chromatin conformation (log2 open = 2.73). The 200-kb region displayed is gene dense, including two WNT genes, is highly enriched in SINE repeat elements, and shows a paucity of LINE, LTR, and DNA transposons.