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Table 1 Comparison of evolutionary rate among three groups of genes

From: Further understanding human disease genes by comparing with housekeeping genes and other genes

  UEHGs Disease genes Other genes
  Mean(SEM) Median Range Mean(SEM) Median Range Mean(SEM) Median Range
Ka 0.053 (0.0015) 0.033 0–0.48 0.080 (0.0017) 0.061 0–0.70 0.092 (8.0E-4) 0.066 0–1.37
Ks 0.58 (0.0047) 0.57 0.076–2.0 0.63 (0.0043) 0.61 0.14–2.4 0.66 (0.0022) 0.62 0.041–4.2
Ka/Ks 0.088 (0.0023) 0.059 0–0.59 0.12 (0.0023) 0.10 0–0.70 0.13 (0.001) 0.11 0–1.2
  1. Ka, the number of non-synonymous substitutions per non-synonymous sites. Ks, the number of synonymous substitutions per synonymous site. Ka and Ks values are calculated based on human-mouse orthologous pairs as described in the main text. The first column in each group is the mean followed by standard error of the mean (SEM).