Figure 1From: The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNAChemical structures and relative ratios of double-strand to single-strand lesions generated. Three enediynes were used for treatment in S. cerevisiae including calicheamicin γ1I, esperamicin A1 and neocarzinostatin. Each of these results in varying ratios of double-strand (DS) to single-strand (SS) lesions in DNA as outlined in Table 1.Back to article page