Figure 4

(A) Visualization of chromosome 17 of the breast cancer cell line MCF7 across multiple array CGH platforms using the May 2004 genomic build. The four platforms are labeled above each ratio plot. The architecture of the chromosome is consistent across all four platforms, with the altered region highlighted in yellow seen clearly across 3 of the 4 platforms. (B) Visualization of chromosome 16 of the same breast cancer cell line, illustrating decreased density of markers in 3 of the 4 array platforms, with the SMRT array providing greater coverage to a region centromeric to band 16p13.11.