Table 1 As the threshold stringency increases, the number of known imprinted genes identified as differentially expressed at a q < 0.05 reaches a local optimum while the number of significant genes decreases.

Effects of filtering at various thresholds on the Affymetrix Human array

Filter Thresholds

PM Threshold

Number of Probes After Filtering

% Probes After Filtering

% Probe Sets Remaining

Number Significant (q < 0.05)

Number Known Imprinted (q < 0.05)

Number Significant (p_adj< 0.05)

Number Known Imprinted (p_adj< 0.05)