Figure 5

Linkage disequilibrium between SNPs in 3 genes from the estradiol metabolising pathway situated within 1 cM on chromosome 15: CYP19, CYP11 and CYP1A. Samples in each row, variants in columns, high frequency allele – blue, low frequency allele- yellow (A). LD was observed between the 3 SNPs in the 3'UTR of CYP19 and 2 SNPs in CYP1A1 and the variant allele of CYP11 with one SNP in CYP19 and another in CYP1A1, bold in panel (B). D', R and Fisher exact test values for all 8 SNPs in this chromosomal area (Site 1–8) are given in panel (B) and Fisher exact test results in colour diagram – blue approximating 0.00(C). Individuals carrying these haplotypes had more often estradiol levels above median (D).