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Figure 2 | BMC Genomics

Figure 2

From: Specific age related signatures in Drosophila body parts transcriptome

Figure 2

Analysis of body part gene specificity. a) Schematic distribution in a Venn diagram of the 2019 probe sets presenting a statistically significant enrichment or depletion in head or thorax compared to whole body after SAM analysis with a fold changeof 1.5. b) Evolution of the number of genes enriched in head or thorax with increasing fold change compared to whole body. c) Clustering of the responsive probesets. The first and second columns contain the cluster number for body part analysis and the number of probe sets in each cluster, respectively. The last four columns contain the mean value of the fold change compared to whole body for all the members of the cluster for the four different conditions (head or thorax at 3 or 40 days). Black or gray areas emphasize significant positive (enrichment) or negative (depletion) fold changes, respectively. Note that since the cluster 12 contains a large number of probe sets (676) that are depleted in both head and thorax compared to whole body, it should therefore be interpreted as containing genes enriched in the fly abdomen. d) Exemples of tissue specific UAS-LacZ or UAS-GFP expression driven by GAL4 enhancer trap insertions located inside the regulatory regions of head or thorax enriched genes. The corresponding genes are the head enriched genes SoxN (NP103525), spir (NP104325), CdsA (NP103768), CG31241 (NP105457) and the thorax enriched gene CG9572 (NP104417). In the latter two cases these expression data may give some indication of the role of these genes of unknown function.

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