Figure 4

Comparisons between previously published stem cell signatures. A. Our study. Overlap between differentially expressed genes at 36, 72 and 96 hours after Lhx2 expression was down-regulated. The intersections between groups of differentially expressed genes are visualized using Venn-diagrams (for clarity not drawn to proportions). The numbers refer to unique genes. B-C. Comparison between the transcripts differentially expressed in our study and two previously published hematopoietic stem cell-enriched gene expression signatures. Signature 1 (B) is derived from the [30] study and Signature 2 (C) from the [29] study. Transcripts that are differentially expressed in our study at all three time-points are included. The overlapping transcripts are further split into transcripts that are up- and down-regulated in our study. Comparison between our data set and the two HSC signatures was carried out on the UniGene transcript level (UniGene build 147).