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Table 4 The most regulated groups genes. Enriched biological processes (level 3), molecular function and chromosome distribution as defined by Gene Ontology and pathways as defined by Kegg of the differentially expressed genes.

From: Global gene expression analyses of hematopoietic stem cell-like cell lines with inducible Lhx2 expression

Categorial system Differential Expression Term Genes p-value
Biological processes Down-regulated REGULATION OF SIGNAL TRANSDUCTION 4 0.015
   ORGANOGENESIS 10 0.070
   CELL DEATH 6 0.077
  Up-regulated ALCOHOL METABOLISM 16 0.00000000000087
   MACROMOLECULE METABOLISM 38 0.0000080
   BIOSYNTHESIS 19 0.000086
   CATABOLISM 16 0.00064
   COENZYME AND PROSTHETIC GROUP METABOLISM 6 0.0028
   VITAMIN METABOLISM 3 0.035
   AMINE METABOLISM 5 0.063
Molecular function Down-regulated TRANSFERASE ACTIVITY, TRANSFERRING GLYCOSYL GROUPS 6 0.013
   OXIDOREDUCTASE ACTIVITY, ACTING ON PEROXIDE AS ACCEPTOR 3 0.030
   PROTEASE INHIBITOR ACTIVITY 4 0.087
  Up-regulated CARBOHYDRATE KINASE ACTIVITY 3 0.0096
   TRANSFERASE ACTIVITY, TRANSFERRING PHOSPHORUS-CONTAINING GROUPS 12 0.013
   CARBON-OXYGEN LYASE ACTIVITY 3 0.054
   PURINE NUCLEOTIDE BINDING 15 0.061
Chromosome Down-regulated 2 17 0.053
  Up-regulated 8 12 0.021
Kegg pathways Up-regulated PENTOSE PHOSPHATE PATHWAY 6 0.0000029
   GLYCOLYSIS / GLUCONEOGENESIS 10 0.00011
   GALACTOSE METABOLISM 5 0.00018
   FRUCTOSE AND MANNOSE METABOLISM 5 0.00061
   CARBON FIXATION 4 0.0018
   STARCH AND SUCROSE METABOLISM 4 0.026