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Table 3 Examples of TCDD-elicited gene expression responses unique to C57BL/6 hepatic tissue

From: In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

Accession

Gene name

Gene Symbol

Entrez Gene ID

Fold changea

Time pointsb (hrs)

AA170585

carbonic anhydrase 3

Car3

12350

-3.5

12c, 18, 24, 168

AK003232

carbonyl reductase 3

Cbr3

109857

2.2

12, 18c

AA571998

CD3 antigen, delta polypeptide

Cd3d

12500

-2.4

12, 18c, 24, 72, 168

BG072496

ELOVL family member 5, elongation of long chain fatty acids

Elovl5

68801

2.0

8, 12c, 18, 24, 72, 168

BG072453

epoxide hydrolase 1, microsomal

Ephx1

13222

1.9

8, 12 18, 24c

W84211

growth arrest specific 1

Gas1

14451

-1.9

4, 8, 18, 24, 72, 168c

W41175

glycerol phosphate dehydrogenase 2, mitochondrial

Gpd2

14571

-2.3

8, 12, 18, 24, 72c, 168

W29265

glutathione S-transferase, alpha 2 (Yc2)

Gsta2

14858

7.2

12, 18, 24, 72c, 168

AA145865

lymphocyte antigen 6 complex, locus A

Ly6a

110454

2.5

72, 168c

W98998

Notch gene homolog 1 (Drosophila)

Notch1

18128

3.3

2, 4c, 8, 12, 18, 24, 72, 168

  1. aMaximum absolute fold change determined by microarray analysis
  2. bDifferentially regulated genes with P1(t) > 0.9999 and |fold change| > 1.5
  3. cTime point representing the maximum |fold change|