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Table 3 Examples of TCDD-elicited gene expression responses unique to C57BL/6 hepatic tissue

From: In vivo – in vitro toxicogenomic comparison of TCDD-elicited gene expression in Hepa1c1c7 mouse hepatoma cells and C57BL/6 hepatic tissue

Accession Gene name Gene Symbol Entrez Gene ID Fold changea Time pointsb (hrs)
AA170585 carbonic anhydrase 3 Car3 12350 -3.5 12c, 18, 24, 168
AK003232 carbonyl reductase 3 Cbr3 109857 2.2 12, 18c
AA571998 CD3 antigen, delta polypeptide Cd3d 12500 -2.4 12, 18c, 24, 72, 168
BG072496 ELOVL family member 5, elongation of long chain fatty acids Elovl5 68801 2.0 8, 12c, 18, 24, 72, 168
BG072453 epoxide hydrolase 1, microsomal Ephx1 13222 1.9 8, 12 18, 24c
W84211 growth arrest specific 1 Gas1 14451 -1.9 4, 8, 18, 24, 72, 168c
W41175 glycerol phosphate dehydrogenase 2, mitochondrial Gpd2 14571 -2.3 8, 12, 18, 24, 72c, 168
W29265 glutathione S-transferase, alpha 2 (Yc2) Gsta2 14858 7.2 12, 18, 24, 72c, 168
AA145865 lymphocyte antigen 6 complex, locus A Ly6a 110454 2.5 72, 168c
W98998 Notch gene homolog 1 (Drosophila) Notch1 18128 3.3 2, 4c, 8, 12, 18, 24, 72, 168
  1. aMaximum absolute fold change determined by microarray analysis
  2. bDifferentially regulated genes with P1(t) > 0.9999 and |fold change| > 1.5
  3. cTime point representing the maximum |fold change|