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Table 1 Multivariate Cox proportional hazards analysis of (A) standard clinical factors alone, or with (B) the Intrinsic Subtypes in relation to Relapse-Free Survival for the 315-sample combined test set. Size was a binary variable (0 = diameter of 2 cm or less, 1 = greater than 2 cm); node status was a binary variable (0 = no positive nodes, 1 = one or more positive nodes); age was a continuous variable formatted as decade-years. Hazard ratios for Intrinsic Subtypes were calculated relative to the Luminal A subtype. Variables found to be significant (p < 0.05) in the Cox proportional hazards model are shown in bold.

From: The molecular portraits of breast tumors are conserved across microarray platforms

A. Relapse-Free survival
Variable Hazard Ratio (95% CI) p-value
Age, per decade 1.04 (0.90–1.20) 0.64
ER status 0.59 (0.41–0.83) 0.003
Node status 1.41 (0.98–2.04) 0.07
Tumor grade 2 vs. 1 2.41 (1.08–5.36) 0.032
Tumor grade 3 vs. 1 3.98 (1.80–8.82) 0.0007
Size 1.60 (1.31–1.95) <0.0001
B. Relapse-Free survival
Variable Hazard Ratio (95% CI) p-value
Age, per decade 1.08 (0.94–1.24) 0.29
ER status 0.69 (0.42–1.13) 0.14
Node status 1.35 (0.92–1.98) 0.13
Tumor grade 2 vs. 1 1.88 (0.82–4.32) 0.14
Tumor grade 3 vs. 1 2.58 (1.08–6.12) 0.03
Size 1.59 (1.30–1.95) <0.0001
Basal-like vs. LumA 2.02 (1.05–3.90) 0.036
HER2+/ER- vs. LumA 3.47 (1.78–6.76) 0.0003
LumB vs. LumA 1.92 (1.07–3.45) 0.028
IFN vs. LumA 1.40 (0.67–2.91) 0.37
Normal-like vs. LumA 1.56 (0.59–4.16) 0.37