Table 1 Threading of Sho primary structures onto the left-handed parallel β-helical sequence 3D profile

Human (41–65)

G

G

A

R

G

A

S

R

V

R

V

X^a

X^a

G

S

S

L

R

R. macaque (41–65)

G

G

A

R

G

T

S

R

V

R

V

X^a

X^a

G

S

S

L

R

Mouse (40–61)

G

G

A

R

G

A

S

R

V

R

V

X^a

X^a

G

S

S

L

R

Rat (40–61)

G

G

A

R

G

A

S

R

V

R

V

X^a

X^a

S

S

S

L

R

Bovine (37–58)

-

G

G

R

G

A

A

R

V

R

V

X^a

X^a

G

S

S

M

R

Dog (41–63)

G

G

A

R

G

A

P

R

V

R

V

X^a

X^a

G

S

S

L

N

Species (residues in Sho)

Rung 2. Human, r. macaque, bovine: V = 114ų; mouse, rat: V = 152ų; dog: V = 121ų

L1

L2

L3

L4

L5

L6

L1'

L2'

L3'

L4'

L5'

L6'

L1"

L2"

L3"

L4"

L5"

L6"

Human (66–82)

-

V

A

A

A

G

A

A

A

G

A

A

A

G

A

A

A

G

R. macaque (66–82)

-

V

A

A

A

G

A

A

A

G

A

A

A

G

A

A

A

G

Mouse (62–78)

-

V

A

A

A

G

A

A

A

G

A

A

A

G

V

A

A

G

Rat (62–78)

-

V

A

A

A

G

A

A

A

G

A

A

A

G

V

A

A

G

Bovine (59–74)

-

V

A

A

G

A

-

A

A

G

A

A

A

G

A

A

A

G

Dog (64–78)

-

V

A

A

A

G

-

A

A

A

G

A

-

G

A

S

T

G

Species (residues in Sho)

Rung 3. Human, r. macaque: V = 224ų; mouse, rat: V = 256ų; bovine: V = 258ų; dog: V = 234ų

L1

L2

L3

L4

L5

L6

L1'

L2'

L3'

L4'

L5'

L6'

L1"

L2"

L3"

L4"

L5"

L6"

Human (83–100)

L

A

A

G

S

G

W

R

R

A

A

G

P

G

E

R

G

L

R. macaque (83–100)

L

A

A

G

S

G

W

R

R

A

A

G

P

G

E

R

G

L

Mouse (79–96)

L

A

T

G

S

G

W

R

R

T

S

G

P

G

E

L

G

L

Rat (79–96)

L

A

T

G

S

G

W

R

R

T

S

G

P

G

E

L

G

L

Bovine (75–91)

L

A

A

G

S

S

W

R

R

A

A

G

-

P

A

E

L

G

Dog (79–93)

-

L

A

A

G

S

-

S

W

R

R

A

-

P

G

L

G

E