Sequence alignment of LRR domains within the six families of TLRs. (1) hTLR1 [Q15399]; hTLR2 [O60603]; hTLR6 [Q9Y2C9]; hTLR10 [Q9BXR5]; tTLR14 [Q5H726]. (2) hTLR3 [O15455]; jfTLR3 [Q76CT7]. (3) hTLR4 [O00204]; dTLR4 [Q8SQH3]. (4) hTLR5 [O60602]. (5) mTLR11 [Q6R5P0]; mTLR12 [Q6QNU9]; mTLR13[Q6R5N8]: tTLR21 [NP_001027751]; tTLR22 [Q5H723]; tTLR23 [AAW70378]; (6) hTLR7 [Q9NYK1]; hTLR8 [Q9NR97]; hTLR9 [Q9NR96]. (7) jlTLRa [Q33E93]; cTLR15 [ABB71177]. The complete amino acid sequences are shown for hTLR1 with 786 residues (res.), hTLR2 with 784 res, hTLR6 with 796 res., hTLR10 with 811 res., tTLR14 with 871 res., hTLR3 with 904 res., jfTLR3 with 961 res., hTLR4 with 839 res., dTLR4 with 636 res., hTLR5 with 858 res., hTLR7 with 1049 res., hTLR8 with 1041 res., hTLR9 with 1032 res., mTLR11 with 926 res., mTLR12 with 906 res., mTLR13 with 991 res., tTLR21 with 965 res., tTLR22 with 950 res., tTLR23 with 941res., jlTLRa with 813res., and cTLR15 with 868 res., Cysteine is highlighted in magenta. Its boldface indicates cysteines in LRRNT or LRRCT. Residues of missense mutation are highlighted in blue boldface. SIGNAL, signal peptide sequence; LRRNT, the cysteine clusters on the N-terminal side of LRRs; LRRCT, the cysteine clusters on the C-terminal side of LRRs; TRANS, transmembrane region; CYTOP, cytoplasmic region. Abbreviations: h, human; m, mouse; t, Takifugu rubripes; c, chicken; d, dog; jf, Japanese flounder. This panel shows hTLR1, hTLR2, jfTLR2 and TLR6 in the TLR1 family.