Table 2 Functional classification of CAGpolyQ genes: Gene Ontology over-representation analysis.
From: CAG-encoded polyglutamine length polymorphism in the human genome
Gene Ontology term (levels) GO ID | Candidate genes in GO term | Fold* Enrichment |
|---|---|---|
Biological Process | Â | Â |
regulation of biological process (1) GO:0050789 | 37 | 2.3 |
regulation of physiological process (2) GO:0050791 | 36 | 2.5 |
regulation of metabolism (3) GO:0019222 | 29 | 3.0 |
positive regulation of metabolism (4) GO:0009893 | 7 | 6.5 |
nucleobase, nucleoside, nucleotide and nucleic acid | Â | Â |
metabolism (4) GO:0006139 | 34 | 2.5 |
Molecular Function | Â | Â |
transcription regulator activity (1) GO:0030528 | 24 | 4.0 |
transcription cofactor activity (2, 4) GO:0003712 | 11 | 8.8 |
transcription coactivator activity (3,5) GO:0003713 | 9 | 13.4 |
nucleic acid binding (2) GO:0003676 | 35 | 2.8 |
DNA binding (3) GO:0003677 | 28 | 3.1 |
transcription factor binding (3) GO:0008134 | 12 | 8.3 |
Cellular Component | Â | Â |
organelle (1) GO:0043226 | 43 | 1.7 |
membrane-bound organelle (2) GO:0043227 | 43 | 1.9 |
intracellular (2) GO:0005622 | 47 | 1.5 |
intracellular organelle (2, 3) GO:0043229 | 43 | 1.7 |
intracellular membrane-bound organelle (3,4) GO:0043231 | 43 | 1.9 |
nucleus (3,4,5) GO:0005634 | 41 | 2.7 |
nucleoplasm (4,5, 6) GO:0005654 | 11 | 4.1 |