Figure 6

Temporal comparison of genes commonly activated by TAM and EE. Hierarchical clustering of 1209 TAM- and EE-regulated genes (y-axis) identifies subsets of similar profiles according to time and treatment (x-axis). The dendrogram indicates that early responses (4 hrs) to ethynylestradiol (E) are most similar to 8 and 12 hrs tamoxifen (T) responses demonstrating temporally displaced TAM activation consistent with the delayed absorption of TAM. However, temporal displacement of TAM elicited responses is not maintained as EE and TAM responses cluster together at 24 and 72 hrs.