Figure 3

Detection of cellular or genetic heterogeneity in meningioma samples. The array-CGH plots follow the same general scheme as for Figure 3. However, the data points are shaded in grey and a trend line (with a moving average of 10 data points) is shown, which highlights the difference in fluorescent ratio levels along the chromosome. A) Identification of genetic heterogeneity in meningioma sample M96 which displays 3 different fluorescent ratio values across chromosome 22. The clone IDs and A verage N ormalized I nter L ocus F luorescence R atio (ANILFR) for each of these are 1–15, 0.95; 16–84, 1.1 and 85–480, 0.83, respectively. B) Array-CGH profile of a complex set of aberrations on chromosome 22, which suggest genetic/cellular heterogeneity within the tumor M90. The regional shifts in fluorescent ratio across chromosome 22 are as summarized with the clone IDs and their ANILFR value; 1–23, 0.95; 24–66, 0.90; 67–214, 0.76; 215–284, 0.88; 285–303, 1.09; 304–326, 0.87; 327–480, 0.76. The non-chromosome 22 autosomal controls have an ANILFR value of 1.00, since this value was used to normalize all values across the genomic array.