Figure 1

Genes associated with hormone independence in breast cancer share significant overlap with genes associated with hormone independence in prostate cancer. Venn diagram showing the overlap between the following sets of genes: (1) genes more highly expressed in clinical ER- over ER+ breast tumors (p<0.01 in each of the RNA profile datasets from van de Vijver et al. and Wang et al.), (2) genes more highly expressed in ER- over ER+ cell lines (p<0.01 in the profile dataset from Bild et al.), and (3) genes more highly expressed in androgen independent (AI) over androgen sensitive (AS) prostate cell lines (p<0.05 in the dataset from Zhao et al.). Core breast ER-status signature, genes shared between the clinical breast tumor and breast cancer cell line sets. Common signature of hormone independence, genes shared between all three sets.