Figure 2

Gene expression patterns of ER- clinical breast cancer are observed in both breast and prostate cancer cell lines. Heat map representation for 2486 unique named genes differentially expressed between ER+ and ER- breast tumors (p<0.01 in both van de Vijver and Wang RNA profile datasets, 1332 higher in ER-). Expression patterns are represented as a color map. Each row represents a gene; each column represents a sample. The level of expression of each gene in each sample is represented using a yellow-blue color scale (yellow: high expression). Patterns corresponding to the 2486 genes are shown in both the Bild profile dataset of 18 breast cancer cell lines (ten ER-) and the Zhao dataset of eight prostate cell lines (AS, androgen sensitive; AI, androgen independent; gray denotes missing values or unrepresented genes). The order of the genes is the same for each of the datasets. Corresponding expression patterns for genes ER, PR, HER2, and EGFR are also shown. The order of the breast and prostate cell lines profiles is the same as that for Figure 4 (where they are labeled by name). Genes and associated expression values are available in Additional File 1.