Figure 3

Gene expression patterns of ER- breast cancer are observed in a subset of clinically localized prostate cancer (PCA). Heat map representation for 417 unique genes differentially expressed between ER+ and ER- clinical breast tumors and cell lines (from Figure 2). The patterns corresponding to these genes are shown in three independent RNA profile datasets of PCA from Glinsky et al. [14], Yu et al. [15], and Lapointe et al. [16]. The PCA profiles are ordered from those that share more similarity with the ER+ breast cancer pattern to those that share more similarity with the ER- breast cancer pattern. The order of the genes is the same for each dataset represented. For each dataset, the average expression of a set of 559 genes induced by synthetic androgen R1881 in vitro in a dataset from Chen et al. [18] is also represented. The order of the breast and prostate cell lines profiles is the same as that for Figure 4. Genes and associated expression values are available in Additional File 2.