In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions

Table 4 Prediction of UTR-SNPs affecting mRNA folding structures.

	number of sequences
distance	dist>10	dist>20	dist>30	dist>40	dist>50	dist>60	dist>70	dist>80	average
Control (min-max)	155 (148–162)	126 (119–137)	104 (97–115)	81 (74–99)	60 (49–82)	38 (30–61)	23 (16–32)	8 (3–12)	20.30 (19.27–23.39)
cancer (n = 358)	179	136	115	94	77	52	20	4	22.85
cancer (permutation positive pool, n = 92)	49	39	32	27	22	17	7	2	25.24*

'Control': average of experiments with UTR-SNPs not associated with cancer phenotype (n = 358, 10 independent control trials). Results were statistically analyzed using the two sample t-test ('*', p < 0.05).

ISSN: 1471-2164