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Table 4 Prediction of UTR-SNPs affecting mRNA folding structures.

From: In silico whole-genome screening for cancer-related single-nucleotide polymorphisms located in human mRNA untranslated regions

  number of sequences  
distance dist>10 dist>20 dist>30 dist>40 dist>50 dist>60 dist>70 dist>80 average
Control (min-max) 155 (148–162) 126 (119–137) 104 (97–115) 81 (74–99) 60 (49–82) 38 (30–61) 23 (16–32) 8 (3–12) 20.30 (19.27–23.39)
cancer (n = 358) 179 136 115 94 77 52 20 4 22.85
cancer (permutation positive pool, n = 92) 49 39 32 27 22 17 7 2 25.24*
  1. 'Control': average of experiments with UTR-SNPs not associated with cancer phenotype (n = 358, 10 independent control trials). Results were statistically analyzed using the two sample t-test ('*', p < 0.05).
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