Comparative analysis of the diverged L. interrogans genomes observed by CGH with respect to their signatures defining genomic islands. (A) The presence/absence CDSs of all tested strains comparing to that of strain Lai ordered from LA0001 to LB367. Red and black areas denote the presence and absence of genes respectively. The blue bar indicates the GI A region, the grey bar indicates the rfb locus, and the yellow bar indicates the GI B region. These 3 regions are specifically drawn to the following sketches indicating the variations in strain Lai for properties of possible genomic islands: CG content (B), genome signature (C), codon usage (D), and amino acid usage (E).