Figure 6From: Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoidsDexamethasone-mediated inhibition of LPS-induced changes in lung tissue TNF-α, BAL fluid TNF-α and BAL neutrophils. Mice were pre-treated either intraperitoneally (-1 hr – A) or orally (-0.5 hr – B/C) with dexamethasone, then exposed to aerosilised LPS and at the indicated time points the tissue levels of TNF-α (A) or BAL TNF-α (B) were determined by sandwich ELISA and inflammatory neutrophilia (C) was determined by differential cell counting. The values give are the means ± SEM obtained from 6 mice.Back to article page