Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations

BMC Genomics

Table 1 Examples of bacteria dependent on folate salvage

*Organism*	*De novo signature enzymes*		*Folate salvage pathway*		*Folate requiring enzymes*			*Folate independent dTMP synthesis*
	FolK	FolP	Dhfr^a	FolC^b	ThyA	GlyA	Fmt	ThyX	Tdk
Lactobacillus acidophilus	-	-	+	+	+	+	+	-	+
Pediococcus pentosaceus	-	-	+	+	+	+	+	-	+
Buchnera aphidicola (3 strains)	-	-	+	+	+	+	+	-	-
Rickettsia rickettsii	-	-	?	+	-	+	+	+	-
Bartonella henselae str. Houston-1	-	-	-	-	+	+	+	-	-
Mycoplasma hyopneumoniae (3 strains)	-	-	-	-	-	+	-	-	+
Mycoplasma genitalium G-37	-	-	+	-	+	+	+	-	+
Mycoplasma synoviae 53	-	-	+	-	+	-	+	-	+
Ureaplasma parvum ATCC 700970	-	-	+	-	-	-	+	-	+
Mesoplasma florum L1	-	-	+	+	+	+	+	-	+
Onion yellows phytoplasma OY-M	-	-	+	+	+	+	-	-	+
Spiroplasma kunkelii CR2-3x	-	-	+	-	+	+	+	-	+
Borrelia burgdorferi B31	-	-	?	-	-	+	+	+	-
Treponema pallidum subsp. pallidum	-	-	?	+	-	+	+	+	-

^a Combination of the presence DHFR0, DHFR1 or DHFR2; ^b Combination of the presence of FolC and FolC2; (+): gene identified; blankcell with (-): no gene identified; (?): predicted missing gene

ISSN: 1471-2164