Figure 1

Alternative splicing pattern of human histone methyltransferase SUV39H2. Representation of the domain structure of three isoforms of SUV39H2, together with their sizes. Shown in red are the two domains, PRE-SET and SET that constitute the catalytic unit of the enzyme. The interaction domain, chromodomain, is shown in green. This domain is seriously damaged in the second isoform, and is unlikely to play any targeting role. The catalytic unit, on the contrary, remains intact in this second isoform, but is clearly damaged in the third isoform, with 28 % of the SET domain and the whole PRE-SET domain missing.