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Table 3 Multivariate Cox Proportional Hazards analysis of EGFR clusters with clinical parameters in NKI295 data set

From: EGFR associated expression profiles vary with breast tumor subtype

  Relapse Free Survival Overall Survival
Variable Hazard Ratio (95% CI) p-value Hazard Ratio (95% CI) p-value
Standard clinical parameters
Age, per decade 0.59 (0.43–0.81) 0.001 0.67 (0.45–0.99) 0.04
ER status 0.64 (0.42–0.98) 0.04 0.45 (0.27–0.71) 0.0009
Size 1.38 (0.94–2.02) 0.10 1.50 (0.94–2.41) 0.09
Tumor grade 2 vs. 1 2.41 (1.31–4.43) 0.005 4.30 (1.48–12.35) 0.007
Tumor grade 3 vs. 1 2.58 (1.38–4.81) 0.003 6.02 (2.09–17.35) 0.0009
Nodes 1–3 vs. 0 0.85 (0.55–1.32) 0.48 0.91 (0.53–1.56) 0.72
Nodes >3 vs. 0 1.37 (0.83–2.26) 0.22 1.56 (0.85–2.85) 0.14
Standard clinical parameters and Cluster #1
Age, per decade 0.59 (0.43–0.82) 0.002 0.67 (0.45–0.99) 0.05
ER status 0.67 (0.43–1.04) 0.08 0.45 (0.27–0.75) 0.002
Size 1.35 (0.92–1.99) 0.12 1.48 (0.92–2.39) 0.11
Tumor grade 2 vs. 1 2.26 (1.23–4.18) 0.009 4.13 (1.42–11.98) 0.009
Tumor grade 3 vs. 1 2.21 (1.16–4.22) 0.02 5.34 (1.81–17.74) 0.002
Nodes 1–3 vs. 0 0.82 (0.56–1.27) 0.38 0.86 (0.50–1.50) 0.60
Nodes >3 vs. 0 1.23 (0.73–2.06) 0.43 1.46 (0.79–2.71) 0.23
Cluster #1 med vs. low 1.53 (0.93–2.53) 0.10 1.25 (0.65–2.39) 0.50
Cluster #1 high vs. low 1.70 (1.01–2.88) 0.05 1.43 (0.76–2.69) 0.27
Standard clinical parameters and Cluster #2
Age, per decade 0.60 (0.43–0.83) 0.002 0.67 (0.452–0.99) 0.04
ER status 0.73 (0.46–1.16) 0.18 0.54 (0.32–0.91) 0.02
Size 1.41 (0.96–2.07) 0.08 1.52 (0.94–2.44) 0.09
Tumor grade 2 vs. 1 1.94 (1.05–3.61) 0.04 3.36 (1.15–9.83) 0.03
Tumor grade 3 vs. 1 1.74 (0.90–3.37) 0.10 3.54 (1.20–10.73) 0.02
Nodes 1–3 vs. 0 0.80 (0.52–1.23) 0.31 0.81 (0.47–1.39) 0.44
Nodes >3 vs. 0 1.19 (0.71–1.98) 0.51 1.36 (0.74–2.49) 0.32
Cluster #2 med vs. low 2.13 (1.22–3.71) 0.008 2.10 (0.95–4.64) 0.07
Cluster #2 high vs. low 2.63 (1.44–4.79) 0.002 3.46 (1.58–7.59) 0.002
Standard clinical parameters and Cluster #3
Age, per decade 0.58 (0.42–0.81) 0.001 0.67 (0.45–0.98) 0.04
ER status 0.68 (0.43–1.07) 0.10 0.45 (0.27–0.76) 0.003
Size 1.39 (0.95–2.03) 0.10 1.49 (0.93–2.41) 0.10
Tumor grade 2 vs. 1 2.30 (1.24–4.24) 0.008 4.13 (1.42–12.00) 0.009
Tumor grade 3 vs. 1 2.29 (1.20–4.38) 0.01 5.38 (1.83–15.80) 0.002
Nodes 1–3 vs. 0 0.83 (0.54–1.29) 0.41 0.86 (0.50–1.49) 0.60
Nodes >3 vs. 0 1.30 (0.79–2.16) 0.31 1.47 (0.80–2.70) 0.22
Cluster #3 med vs. low 1.32 (0.81–2.16) 0.26 1.54 (0.80–2.95) 0.20
Cluster #3 high vs. low 1.41 (0.84–2.37) 0.19 1.43 (0.73–2.78) 0.29
  1. Age was a continuous variable grouped in decade years, size was a binary variable (0 = < 2 cm, 1 = > 2 cm), tumor grade 2 and 3 are relative to grade 1, and node status (1–3 nodes or > 3 nodes) was relative to 0 positive nodes. Expression of the three clusters was averaged, rank ordered, divided into equal thirds; medium and high expression is relative to low expression. Significant variables are displayed in bold.