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Table 4 Chi-square analysis for association of gene expression with subtypes

From: EGFR associated expression profiles vary with breast tumor subtype

  Basal-like HER2+/ER- Luminal A Luminal B Normal-like p-value
# tumors 53 35 123 55 29  
Cluster 1a 68% 37% 12% 56% 14% <0.0001
Cluster 2a 89% 49% 5% 49% 7% <0.0001
Cluster 3a 77% 51% 11% 47% 0% <0.0001
EGFRa 68% 20% 27% 18% 41% <0.0001
HER2a 15% 100% 28% 26% 24% <0.0001
HER4* 9% 3% 50% 38% 31% <0.0001
TGFAb 74% 37% 17% 25% 38% <0.0001
AREGa 3% 34% 43% 35% 41% <0.0001
EGF 17% 40% 37% 36% 31% 0.23
CRYABa 70% 11% 33% 4% 48% <0.0001
KRAS amplicona 68% 40% 24% 35% 0% <0.0001
KRAS genec 32% 37% 33% 38% 21% 0.36
HRASd 32% 66% 17% 64% 7% <0.0001
NRASa 70% 28% 17% 44% 21% <0.0001
PIK3CA 30% 17% 36% 36% 41% 0.28
PIK3R1a 21% 14% 42% 25% 55% 0.0012
AKT1a 26% 63% 27% 40% 24% <0.0001
AKT2* 26% 40% 27% 47% 38% 0.26
AKT3a 51% 14% 39% 9% 45% <0.0001
MEK1 53% 46% 25% 29% 24% 0.023
MEK2e 42% 43% 25% 42% 24% 0.068
ERK1f 30% 26% 31% 42% 41% 0.49
ERK2g 40% 31% 26% 45% 31% 0.048
  1. Samples were rank ordered into three equal groups and the percentage of each subtype in the highest expression group is reported for the NKI patient data set.
  2. *Note: HER4 could not be assessed in UNC data due to too many missing values; HER3 was not present in the NKI data set; AKT2 was not present in the UNC data set
  3. a associations were also similarly significant in the UNC sample set
  4. b nominally significant in UNC data (p-value = 0.0046)
  5. c nominally significant association in the UNC data (p-value= 0.0051)
  6. d nominally significant in the UNC data (p-value = 0.003)
  7. e nominally significant in the UNC data (p-value = 0.0023)
  8. f significant in the UNC data (p-value = 0.0003)
  9. g significant in the UNC data (p-value = <0.0001)
  10. Bonferroni corrected level of significance α = 0.0022