New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures

Table 3 bldA-dependent genes for which some direct link to bldA can be proposed

Gene¹	Gene product²	Reference
A: Containing a TTA codon
SCO4262	Hypothetical protein	[55]
SCO6638	Hypothetical protein	[55]
B: Regulated by a TTA-containing gene
By adpA
SCO0762	Protease inhibitor	[55]
By SCO4263
SCO4246	Hypothetical protein	[55]
SCO4251	Putative secreted protein	This study
SCO4252	Hypothetical protein	This study
SCO4253	Conserved hypothetical protein	This study
By act II-ORF4
SCO5071	Hydroxylacyl-CoA dehydrogenase, ActVI-ORFA	[14]
SCO5073	Putative oxidoreductase, ActVI-ORF2	[14]
SCO5074	Putative dehydratase, ActVI-ORF3	[14]
SCO5075	Putative oxidoreductase, ActVI-ORF4	[14]
SCO5078	Hypothetical protein	[14]
SCO5079	Conserved hypothetical protein	[14]
SCO5086	Ketoacyl reductase, ActIII	[14]
SCO5088	Polyketide beta-ketoacyl synthase, ActI-ORF2	[14]
SCO5090	Actinorhodin polyketide cyclase/dehdratase, ActVII	[14]
By redZ
SCO5895	Putative methyltransferase, RedI	[20]
C: In a putative operon with a TTA-containing gene
SCO0392	Putative methyltransferase	[31]
SCO0395	Putative epimerase/dehydratase	[31]
SCO0400	Putative epimerase	[31]
SCO0401	Putative aminotransferase	[31]
SCO0991	Conserved hypothetical protein	[31]
SCO0994	Integral membrane protein	[31]
SCO0995	Probable methyltransferase	[31]
SCO6637	Hypothetical protein	[31]

¹the combined list of 147 bldA-affected genes as determined by transcriptomics and/or proteomics was considered
²from SCODB [55]

ISSN: 1471-2164