Table 2 Relevant functional groups of differentially expressed genes
Function | Genesymbol | Full name |
|---|---|---|
Genes up-regulated in erythroblasts | ||
heme biosynthesis | CPOX | coproporphyrinogen oxidase |
heme biosynthesis | ALAD | aminolevulinate, delta-, dehydratase |
heme biosynthesis | ALAS2 | aminolevulinate, delta-, synthase 2 |
heme biosynthesis | FECH | ferrochelatase (protoporphyria) |
heme biosynthesis | HMBS | hydroxymethylbilane synthase |
heme biosynthesis | PPOX | protoporphyrinogen oxidase |
heme biosynthesis | UROD | uroporphyrinogen decarboxylase |
heme biosynthesis | UROS | uroporphyrinogen III synthase (congenital erythropoietic porphyria) |
erythroid differentiation | GATA1 | GATA binding protein 1 (globin transcription factor 1) |
erythroid differentiation | TAL1/SCL | T-cell acute lymphocytic leukemia 1 |
erythrocytes antigens | DARC | Duffy blood group, chemokine receptor |
erythrocytes antigens | CD58/LFA-3 | CD58 molecule |
erythrocytes antigens | EPB42 | erythrocyte membrane protein band 4.2 |
erythrocytes antigens | ERAF | erythroid associated factor |
erythrocytes antigens | CD36 | CD36 molecule (thrombospondin receptor) |
erythrocytes antigens | GYPE | glycophorin E |
Genes up-regulated in megakaryoblasts | ||
blood coagulation and platelet activation | ADRA2A | adrenergic, alpha-2A-, receptor |
blood coagulation and platelet activation | GP5 | glycoprotein V (platelet) |
blood coagulation and platelet activation | GP6 | glycoprotein VI (platelet) |
blood coagulation and platelet activation | GP9 | glycoprotein IX (platelet) |
blood coagulation and platelet activation | P2RY1 | purinergic receptor P2Y, G-protein coupled, 1 |
blood coagulation and platelet activation | PROS1 | protein S (alpha) |
blood coagulation and platelet activation | THBS1 | thrombospondin 1 |
blood coagulation and platelet activation | VWF | von Willebrand factor |
biosynthesis of steroids | LDLRAP1 | low density lipoprotein receptor adaptor protein 1 |
biosynthesis of steroids | TM7SF2 | transmembrane 7 superfamily member 2 |
biosynthesis of steroids | SREBF1 | sterol regulatory element binding transcription factor 1 |
biosynthesis of steroids | SREBF2 | sterol regulatory element binding transcription factor 2 |
biosynthesis of steroids | CYB5R3 | cytochrome b5 reductase 3 |
biosynthesis of steroids | VLDLR | very low density lipoprotein receptor |
biosynthesis of steroids | ALOX12 | arachidonate 12-lipoxygenase |
biosynthesis of steroids | LTC4S | leukotriene C4 synthase |
biosynthesis of steroids | PTGS1/COX1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) |
biosynthesis of steroids | TBXAS1 | thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) |
Genes up-regulated in myeloblasts | ||
regulation hemopoietic cells proliferation | LIF | leukemia inhibitory factor (cholinergic differentiation factor) |
inflammatory response | ALOX5AP | arachidonate 5-lipoxygenase-activating protein |
regulation of myeloid cells differentiation | TIMP1 | TIMP metallopeptidase inhibitor 1 |
Genes up-regulated in monoblasts | ||
mono/macrophage activation | CD93 | CD93 molecule |
mono/macrophage activation | CD40 | CD40 molecule, TNF receptor superfamily member 5 |
mono/macrophage activation | TLR1 | toll-like receptor 1 |
mono/macrophage activation | TLR6 | toll-like receptor 6 |
mono/macrophage activation | ICAM1 | intercellular adhesion molecule 1 (CD54), human rhinovirus receptor |
mono/macrophage activation | CCL2 | chemokine (C-C motif) ligand 2 |
mono/macrophage activation | FCGR1A | Fc fragment of IgG, high affinity Ia, receptor (CD64) |
mono/macrophage activation | C3AR1 | complement component 3a receptor 1 |
mono/macrophage activation | CD163 | CD163 molecule |
mono/macrophage activation | IFNGR1 | interferon gamma receptor 1 |
mono/macrophage activation | IFNGR2 | interferon gamma receptor 2 (interferon gamma transducer 1) |
mono/macrophage activation | CSF1R | colony stimulating factor 1 receptor |
inflammatory response | IL6 | interleukin 6 (interferon, beta 2) |
inflammatory response | CCR1 | chemokine (C-C motif) receptor 1 |
inflammatory response | IL1RN | interleukin 1 receptor antagonist |
inflammatory response | TLR8 | toll-like receptor 8 |
inflammatory response | PLA2G7 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
inflammatory response | SELPLG | selectin P ligand |
proteins of monocytic granules | CTSB | cathepsin B |
proteins of monocytic granules | CTSD | cathepsin D (lysosomal aspartyl peptidase) |
proteins of monocytic granules | RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) |
proteins of monocytic granules | RNASE6 | ribonuclease, RNase A family, k6 |
proteins of monocytic granules | DNASE2 | deoxyribonuclease II, lysosomal |
fibrogenic cytokine | TGFa | transforming growth factor, alpha |
dendritic cells differentiation | IL3RA | interleukin 3 receptor, alpha (low affinity) |