Volcano plot of genes differentially expressed between trisomic and control samples. The log2 of fold change between trisomic and control samples is represented on the x-axis and the negative log of p-values from the t-test is represented on the y-axis. Genes upregulated in the trisomic samples are on the right of the horizontal axis 0 value; genes downregulated are on the left. Red dots indicate 473 genes that are significantly up- or down-regulated in the trisomic samples compared to the control samples (p < 0.05). Yellow dots indicate genes with no significant variation.