Figure 5

Volcano plots obtained by comparing DS fetuses with and without cardiac defects. Forty-two of the 15,000 analyzed genes are differentially expressed in the 5 samples with cardiac anomalies (CDH) and the 5 samples without cardiac anomalies (DH) (6a). Only a few genes of the ~600 encoding mitochondrial proteins (6b) and of the ~700 encoding ECM proteins (6c), are dysregulated in the CDH vs. DH comparison. Red dots indicate genes differentially expressed with fold change >1.2 and p < .05; yellow dots indicate genes with no significant variation.