Skip to main content

Table 3 Enriched GO categories for down-regulated genes, sorted by p-value of the comparison between observed and expected data

From: Altered expression of mitochondrial and extracellular matrix genes in the heart of human fetuses with chromosome 21 trisomy

GO Category Observed Expected Ratio p-value
Biological Process     
gener. of precursor metabolites and energy 30 9.78 3.07 3.31E-08
oxidative phosphorylation 9 1.28 7.03 4.43E-06
ATP synth. Coupled electron transp. 6 0.49 12.24 6.55E-06
coenzyme metabolism 12 2.65 4.53 1.26E-05
mitochondrial electron transport 5 0.41 12.2 3.84E-05
acetyl-CoA metabolism 5 0.56 8.93 0.000193
electron transport 15 5.51 2.72 0.000408
main pathways of carbohydrate metabolism 8 1.92 4.17 0.00065
glucose catabolism 6 1.15 5.22 0.000966
monosaccharide catabolism 6 1.32 4.55 0.001998
hexose catabolism 6 1.32 4.55 0.001998
energy derivation by oxid. of organic comp. 9 2.84 3.17 0.00214
alcohol catabolism 6 1.35 4.44 0.00217
Glycolysis 5 0.94 5.32 0.002329
porphyrin biosynthesis 3 0.28 10.71 0.002341
porphyrin metabolism 3 0.34 8.82 0.004372
group transfer coenzyme metabolism 5 1.11 4.5 0.004859
cellular carbohydrate catabolism 6 1.73 3.47 0.00756
carbohydrate catabolism 6 1.73 3.47 0.00756
glucose metabolism 6 1.77 3.39 0.008491
Molecular Function     
electron carrier activity 9 1.14 7.89 1.7E-06
NADH dehydrogenase activity 7 0.69 10.14 4.11E-06
hydrogen ion transporter activity 12 2.39 5.02 4.48E-06
oxidoreductase activity, acting on NADH/NADPH 8 1.02 7.84 6.63E-06
sodium ion transporter activity 7 0.75 9.33 7.61E-06
primary active transporter activity 13 3 4.33 8.97E-06
monovalent inorganic cation transporter activity 12 2.58 4.65 9.83E-06
metal ion transporter activity 9 1.56 5.77 2.34E-05
oxidoreductase activity 23 10.05 2.29 0.000172
electron transporter activity 12 4.37 2.75 0.001446
carrier activity 16 6.91 2.32 0.001523
metal cluster binding 4 0.52 7.69 0.001633
iron-sulfur cluster binding 4 0.52 7.69 0.001633
unfolded protein binding 8 2.62 3.05 0.004727
Cellular component     
mitochondrion 48 10.2 4.71 3E-20
mitochondrial envelope 10 2.45 4.08 0.000163
mitochondrial inner membrane 8 1.61 4.97 0.000194
mitochondrial membrane 9 2.07 4.35 0.000217
organelle envelope 13 4.21 3.09 0.000296
envelope 13 4.25 3.06 0.000326
organelle inner membrane 8 1.8 4.44 0.000417
membrane-enclosed lumen 19 8.37 2.27 0.000692
organelle lumen 19 8.37 2.27 0.000692
nucleolus 6 1.82 3.3 0.009655