Table 3 Enriched GO categories for down-regulated genes, sorted by p-value of the comparison between observed and expected data
GO Category | Observed | Expected | Ratio | p-value |
|---|---|---|---|---|
Biological Process | Â | Â | Â | Â |
gener. of precursor metabolites and energy | 30 | 9.78 | 3.07 | 3.31E-08 |
oxidative phosphorylation | 9 | 1.28 | 7.03 | 4.43E-06 |
ATP synth. Coupled electron transp. | 6 | 0.49 | 12.24 | 6.55E-06 |
coenzyme metabolism | 12 | 2.65 | 4.53 | 1.26E-05 |
mitochondrial electron transport | 5 | 0.41 | 12.2 | 3.84E-05 |
acetyl-CoA metabolism | 5 | 0.56 | 8.93 | 0.000193 |
electron transport | 15 | 5.51 | 2.72 | 0.000408 |
main pathways of carbohydrate metabolism | 8 | 1.92 | 4.17 | 0.00065 |
glucose catabolism | 6 | 1.15 | 5.22 | 0.000966 |
monosaccharide catabolism | 6 | 1.32 | 4.55 | 0.001998 |
hexose catabolism | 6 | 1.32 | 4.55 | 0.001998 |
energy derivation by oxid. of organic comp. | 9 | 2.84 | 3.17 | 0.00214 |
alcohol catabolism | 6 | 1.35 | 4.44 | 0.00217 |
Glycolysis | 5 | 0.94 | 5.32 | 0.002329 |
porphyrin biosynthesis | 3 | 0.28 | 10.71 | 0.002341 |
porphyrin metabolism | 3 | 0.34 | 8.82 | 0.004372 |
group transfer coenzyme metabolism | 5 | 1.11 | 4.5 | 0.004859 |
cellular carbohydrate catabolism | 6 | 1.73 | 3.47 | 0.00756 |
carbohydrate catabolism | 6 | 1.73 | 3.47 | 0.00756 |
glucose metabolism | 6 | 1.77 | 3.39 | 0.008491 |
Molecular Function | Â | Â | Â | Â |
electron carrier activity | 9 | 1.14 | 7.89 | 1.7E-06 |
NADH dehydrogenase activity | 7 | 0.69 | 10.14 | 4.11E-06 |
hydrogen ion transporter activity | 12 | 2.39 | 5.02 | 4.48E-06 |
oxidoreductase activity, acting on NADH/NADPH | 8 | 1.02 | 7.84 | 6.63E-06 |
sodium ion transporter activity | 7 | 0.75 | 9.33 | 7.61E-06 |
primary active transporter activity | 13 | 3 | 4.33 | 8.97E-06 |
monovalent inorganic cation transporter activity | 12 | 2.58 | 4.65 | 9.83E-06 |
metal ion transporter activity | 9 | 1.56 | 5.77 | 2.34E-05 |
oxidoreductase activity | 23 | 10.05 | 2.29 | 0.000172 |
electron transporter activity | 12 | 4.37 | 2.75 | 0.001446 |
carrier activity | 16 | 6.91 | 2.32 | 0.001523 |
metal cluster binding | 4 | 0.52 | 7.69 | 0.001633 |
iron-sulfur cluster binding | 4 | 0.52 | 7.69 | 0.001633 |
unfolded protein binding | 8 | 2.62 | 3.05 | 0.004727 |
Cellular component | Â | Â | Â | Â |
mitochondrion | 48 | 10.2 | 4.71 | 3E-20 |
mitochondrial envelope | 10 | 2.45 | 4.08 | 0.000163 |
mitochondrial inner membrane | 8 | 1.61 | 4.97 | 0.000194 |
mitochondrial membrane | 9 | 2.07 | 4.35 | 0.000217 |
organelle envelope | 13 | 4.21 | 3.09 | 0.000296 |
envelope | 13 | 4.25 | 3.06 | 0.000326 |
organelle inner membrane | 8 | 1.8 | 4.44 | 0.000417 |
membrane-enclosed lumen | 19 | 8.37 | 2.27 | 0.000692 |
organelle lumen | 19 | 8.37 | 2.27 | 0.000692 |
nucleolus | 6 | 1.82 | 3.3 | 0.009655 |