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Table 1 Enriched KEGG pathways in the list of differentially expressed genes at 4 h after HAL-PDT

From: Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate

KEGG Pathway Gene Count % P-Value*
Total/Down regulated gene list
oxidative phosphorylation 101/79 1.0 9.1E-10
ribosome 125/119 1.2 2E-07
cell cycle 72/64 0.7 0.0015
citrate cycle (TCA cycle) 22/20 0.2 0.0041
proteasome 25/25 0.2 0.0043
ATP synthesis 32/27 0.3 0.0047
rna polymerase 21/20 0.2 0.0065
ubiquitin mediated proteolysis 32/26 0.3 0.0078
purine metabolism 92/72 0.9 0.011
pyrimidine metabolism 58/49 0.6 0.017
cholera – infection 28/20 0.3 0.02
glycolysis/gluconeogenesis 40/33 0.4 0.023
phenylalanine, tyrosine and tryptophan biosynthesis 10/8 0.1 0.027
propanoate metabolism 26/21 0.3 0.038
insulin signaling pathway 78/59 0.8 0.044
Up-regulated gene list
ubiquinone biosynthesis 8 0.2 0.019
alzheimer's disease 10 0.2 0.022
neuroactive ligand-receptor interaction 74 1.5 0.027
type i diabetes mellitus 14 0.3 0.039
focal adhesion 54 1.1 0.044
fc epsilon ri signaling pathway 23 0.5 0.065
gap junction 27 0.5 0.072
long-term depression 22 0.4 0.076
adherens junction 22 0.4 0.085
porphyrin and chlorophyll metabolism 12 0.2 0.096
hematopoietic cell lineage 24 0.5 0.099
  1. *The gene-enrichment of functional categories was measured by determining the number of genes, belonging to the functional group in the list of modulated genes weigh against to the total analysed genes on arrays (background) using Fisher Exact test.