An evaluation of Comparative Genome Sequencing (CGS) by comparing two previously-sequenced bacterial genomes

BMC Genomics

Table 2 Summary of false negatives/false positives.

Mutation type	No. of real differences^a	No. detected	False negative rate	No. false positive	False positive rate per 10,000 bp
Small sequence differences	8	7	12.50%	19	0.041
IS-element insertions	12	9	25%	15^b	0.032
Deletions/inversions	2	1	50%	15^b	0.032

a. This number only includes those differences reported in reference 13, and not the new ones discovered in this study.
b. The number of non-called ROI's that did not contain mutations was taken as the number of false positives for both IS-element insertions and indels.

ISSN: 1471-2164