Figure 3

Organ-specific microRNAs. (A) Hot maps. The microRNA samples from 6 organs were co-hybridized with the common reference. The signals were processed as described in Materials and Methods. The normalized data were subjected to the SAM test [67]. The miRNAs that passed SAM were further tested by the HSD test (P < 0.05) to identify organ-specific miRNAs. Each column represents one hybridization and each row represents one miRNA. The figure was drawn by Treeview. Red represents positive values, green negative values, and black zero. The number of miRNAs for each organ is: Lung 2; heart 6; brain 13; liver 5; kidney 2 and spleen 18. (B) Summary of differently expressed miRNAs among 6 organs. The number beside each organ represents the number of miRNAs that are expressed significantly higher in this organ than any other organs (P < 0.05). The number on the line between any two organs is the quantity of miRNAs expressed significantly higher in these two organs than in other organs (P < 0.05).