Genomewide high-density SNP linkage analysis of non-BRCA1/2 breast cancer families identifies various candidate regions and has greater power than microsatellite studies

Table 4 Comparative LOD scores in linkage families using SNP-GWS and STR-GWS data both with and without high-density STRs data

Comparative parametric LOD scores (HLOD) under dominant and recessive models using SNP-GWS and STR-GWS; both with and without high-density STRs data in linkage families. Candidate families 8, 3386 and 3568 were excluded since none of them had a parametric LOD score greater than 1.5. NL: values < 1.5 in parametric analysis according to Smith et al [15]. SNP-GWS + STRs: SNP-GWS plus STR fine mapping. STR-GWS + STRs: STR-GWS plus STR fine mapping.

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