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Table 2 Genes showing significant differences in expression between rapid-forming PCTs (ABPC and ABLMYCPC) and slow-forming PCTs (TEPC, IL6PC and KiPC)

From: Gene expression profiling reveals different pathways related to Abl and other genes that cooperate with c-Myc in a model of plasma cell neoplasia

Higher in slow-forming PCT (TEPC, IL6PC, KiPC
Gene function Rapid PCT Slow PCT Fold difference (slow/rapid) Description Unigene ID Gene symbol p-value
Angiogenesis
  308.4 495.6 1.6 Neogenin Mm.42249 Neo1 1.05E-05
Apoptosis
  2872.8 5249.1 1.8 RIKEN cDNA A630035D09 gene Mm.238213 Bcl2l1 4.67E-05
Cell cycle
  583.6 2799.1 4.8 Megakaryocyte-associated tyrosine kinase Mm.2918 Matk < 1E-07
  270.1 912.6 3.4 Protein kinase C, zeta Mm.28561 Prkcz < 1E-07
  208.1 364.3 1.8 Acid phosphatase, prostate Mm.19941 Acpp 2.10E-06
  280.7 473.5 1.7 Cyclin D1 Mm.273049 Ccnd1 7.12E-05
  1484.3 2441.1 1.6 Casein kinase 1, epsilon Mm.30199 Csnk1e 3.50E-06
Immune response
  204.1 535.4 2.6 Prolactin receptor Mm.10516 Prlr 5.4E-06
  124 267.7 2.2 Transforming growth factor, beta receptor III Mm.200775 Tgfbr3 1.2E-06
  2872.8 5249.1 1.8 RIKEN cDNA A630035D09 gene Mm.238213 Bcl2l1 4.67E-05
  707.2 1243.1 1.8 AU RNA binding protein/enoyl-coenzyme A hydratase Mm.252034 Auh 3.2E-06
  1000.1 1751.7 1.8 Aldehyde dehydrogenase 2, mitochondrial Mm.284446 Aldh2 3.56E-05
  2990.5 5228.6 1.7 Glucosidase, beta, acid Mm.5031 Gba < 1E-07
  942.5 1629.7 1.7 AU RNA binding protein/enoyl-coenzyme A hydratase Mm.252034 Auh < 1E-07
  7349 12562.5 1.7 CCAAT/enhancer binding protein (C/EBP), beta Mm.347406 Cebpb 1E-07
  752.1 1285.1 1.7 Profilin 1 Mm.2647 Pfn1 3.5E-06
  912.2 1538.3 1.7 Aldehyde dehydrogenase 2, mitochondrial Mm.284446 Aldh2 6.2E-05
  2311.2 3862.5 1.7 Epidermal growth factor receptor pathway substrate 15 Mm.318250 Eps15 1.24E-05
  166.2 274.5 1.7 Microphthalmia-associated transcription factor Mm.333284 Mitf 7.9E-06
  722.3 1097.6 1.5 Amyloid beta (A4) precursor protein-binding, family B, member 1 Mm.38469 Apbb1 7E-06
  749.6 1135 1.5 Glutathione synthetase Mm.252316 Gss 7.61E-05
Transcription factor
  294 803.5 2.7 AT motif binding factor 1 Mm.196564 Atbf1 < 1e-07
  247.9 639.4 2.6 E74-like factor 3 Mm.3963 Elf3 6.80E-06
  844.6 1883 2.2 Pre B-cell leukemia transcription factor 1 Mm.43358 Pbx1 < 1E-07
  765.9 1554.6 2.0 POU domain, class 2, transcription factor 2 Mm.208700 Pou2f2 2.30E-06
  7349 12562.5 1.7 CCAAT/enhancer binding protein (C/EBP), beta Mm.347406 Cebpb 1.00E-07
  162.2 252.2 1.6 RIKEN cDNA 2310011G17 gene Mm.254233 2310011G17 Rik 6.55E-05
Signal transduction
  583.6 2799.1 4.8 Megakaryocyte-associated tyrosine kinase Mm.2918 Matk < 1E-07
  270.1 912.6 3.4 Protein kinase C, zeta Mm.28561 Prkcz < 1E-07
  1484.3 2441.1 1.6 Casein kinase 1, epsilon Mm.30199 Csnk1e 3.50E-06
  456.5 729.4 1.6 Homeodomain interacting protein kinase 3 Mm.257925 Hipk3 2.11E-05
Development
  844.6 1883 2.2 Pre B-cell leukemia transcription factor 1 Mm.43358 Pbx1 < 1E-07
Higher in rapid-forming PCT (ABPC and ABLMYCPC)
Gene function Rapid PCT Slow PCT Fold difference (rapid/slow) Description Unigene ID Gene symbol p-value
Angiogenesis
  1868.3 902.8 2.1 Plasminogen activator, urokinase Mm.4183 Plau 8.29E-05
  9821.9 4360.2 2.3 CD53 antigen Mm.316861 Cd53 3.40E-06
Apoptosis
  2588.3 1681.2 1.5 BCL2-antagonist/killer 1 Mm.2443 Bak1 9.11E-05
Cell cycle
  2231.6 1126.6 2.0 Proliferation-associated 2G4 Mm.4742 Pa2g4 2.76E-05
  4858.7 2552.3 1.9 Adenylate kinase 2 Mm.29460 Ak2 < 1E-07
  10477 6082.1 1.7 CDC28 protein kinase regulatory subunit 2 Mm.222228 Cks2 < 1E-07
  1371.5 869.3 1.6 Casein kinase II, alpha 2, polypeptide Mm.51136 Csnk2a2 1.90E-06
Immune response
  3568.1 386 9.2 CD6 antigen Mm.290897 Cd6 2.00E-07
  984.7 186.1 5.3 Tubulin, alpha 3 Mm.287784 Tuba3 < 1E-07
  2661.9 718.2 3.7 BH3 interacting domain death agonist Mm.235081 Bid < 1E-07
  7492.6 2554.5 2.9 Acetyl-Coenzyme A dehydrogenase, medium chain Mm.10530 Acadm < 1E-07
  3195.6 1346.2 2.4 Inositol (myo)-1(or 4)-monophosphatase 1 Mm.183042 Impa1 < 1E-07
  2455 1064.3 2.3 RAS-related protein-1a Mm.333868 Rap1a < 1E-07
  9821.9 4360.2 2.3 CD53 antigen Mm.316861 Cd53 3.40E-06
  7479.7 3365.9 2.2 Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Mm.207996 Tap1 < 1E-07
  7347.8 3535.9 2.1 Superoxide dismutase 1, soluble Mm.276325 Sod1 < 1E-07
  365.9 179.9 2.0 Growth factor independent 1 Mm.2078 Gfi1 1.30E-05
  2231.6 1126.6 2.0 Proliferation-associated 2G4 Mm.4742 Pa2g4 2.76E-05
  1939.9 985.5 2.0 RAS-related protein-1a Mm.333868 Rap1a 4.00E-07
  450.3 261.9 1.7 Ets variant gene 4 (E1A enhancer binding protein, E1AF) Mm.5025 Etv4 1.40E-06
  3031.7 1830.6 1.7 Wiskott-Aldrich syndrome homolog (human) Mm.4735 Was 5.13E-06
  3136.7 1944.6 1.6 Chromosome segregation 1-like (S. cerevisiae) Mm.22417 Cse1l 2.67E-05
  5738.7 3586.7 1.6 Survival motor neuron 1 Mm.2025 Smn1 2.75E-05
  395.2 252.8 1.6 Dihydrofolate reductase Mm.23695 Dhfr 2.70E-06
  2017.5 1297.8 1.6 FK506 binding protein 12-rapamycin associated protein 1 Mm.21158 Frap1 8.46E-05
  2588.3 1681.2 1.5 BCL2-antagonist/killer 1 Mm.2443 Bak1 9.11E-05
  4410.1 2873.4 1.5 Ribonucleotide reductase M1 Mm.197486 Rrm1 5.14E-05
  5971.6 3940.2 1.5 Integrin beta 4 binding protein Mm.271674 Itgb4bp 6.94E-05
  18860.1 12494.5 1.5 Triosephosphate isomerase 1 Mm.4222 Tpi1 8.30E-06
Transcription factor
  6231.6 1885.8 3.3 Lymphoblastomic leukemia Mm.4925 Lyl1 < 1E-07
  3274.2 1544.3 2.1 Chromodomain helicase DNA binding protein 1 Mm.8137 Chd1 < 1E-07
  450.3 261.9 1.7 Ets variant gene 4 (E1A enhancer binding protein, E1AF) Mm.5025 Etv4 1.40E-06
  3136.7 1944.6 1.6 Chromosome segregation 1-like (S. cerevisiae) Mm.22417 Cse1l 2.67E-05
Signal transduction
  4858.7 2552.3 1.9 Adenylate kinase 2 Mm.29460 Ak2 < 1E-07
  10477 6082.1 1.7 CDC28 protein kinase regulatory subunit 2 Mm.222228 Cks2 < 1E-07
  3031.7 1830.6 1.7 Wiskott-Aldrich syndrome homolog (human) Mm.4735 Was 5.13E-05
  1371.5 869.3 1.6 Casein kinase II, alpha 2, polypeptide Mm.51136 Csnk2a2 1.90E-06
DNA replication
  3805.2 2420.4 1.6 Small nuclear ribonucleoprotein polypeptide A' Mm.821 Snrpa1 < 1e-07
  8247.5 4325.9 1.9 Replication protein A1 Mm.180734 Rpa1 4.20E-06
  1. Class comparison between slow-forming PCTs (TEPC, IL6PC and KiPC) and rapid-forming PCTs (ABPC and ABLMYCPC) by two-sample t-test generated 1195 genes showing significant differences (p- value < 0.001). Among these 1195 genes, the genes showing more than 1.5 fold increase and p-value < 0.0001 were selected in this table. The genes in each category of gene function were assigned based on the annotation of CGAP.