Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes

Rios, Jonathan J; Perelygin, Andrey A; Long, Maureen T; Lear, Teri L; Zharkikh, Andrey A; Brinton, Margo A; Adelson, David L

doi:10.1186/1471-2164-8-313

Table 6 Equine RNASEL single nucleotide polymorphisms

From: Characterization of the equine 2'-5' oligoadenylate synthetase 1 (OAS1) and ribonuclease L (RNASEL) innate immunity genes

Region	AccessionEF070193	Alleles	Residue	Amino Acid Type	Frequency	Polymorphism
-	143	C	-	-	0.12	Transversion
		G			0.88
5' UTR	1857	A	-	-	0.55	Transversion
		C			0.45
Exon 2	1991	C	27His	Basic Polar	0.54	Transition
		T	27Tyr	Uncharged Polar	0.46
Exon 2	2020	C	36Gly	Uncharged Polar	0.92	Transition
		T	36Gly		0.08
Exon 2	2021	G	37Asp	Acidic Polar	0.69	Transversion
		T	37Tyr	Uncharged Polar	0.31
Exon 2	2118	A	69Asn	Uncharged Polar	0.29	Transversion
		C	69Thr	Uncharged Polar	0.71
Exon 2	2121	A	70Tyr	Uncharged Polar	0.92	Transition
		G	70Cys	Uncharged Polar	0.08
Exon 2	2316	A	135Lys	Basic Polar	0.75	Transversion
		C	135Thr	Uncharged Polar	0.25
Exon 2	2332	A	140Ala	Nonpolar	0.35	Transition
		G	140Ala		0.65
Exon 2	2374	G	154Arg	Basic Polar	0.83	Transversion
		T	154Ser	Uncharged Polar	0.17
Exon 2	2635	A	241Thr	Uncharged Polar	0.21	Transition
		G	241Thr		0.79
Exon 2	2680	C	256Ser	Uncharged Polar	0.43	Transversion
		G	256Ser		0.57
Exon 2	2771	A	287Lys	Basic Polar	0.57	Transition
		G	287Glu	Acidic Polar	0.43
Exon 2	3144	A	411Asn	Uncharged Polar	0.19	Transition
		G	411Ser	Uncharged Polar	0.81
Exon 2	3152	C	414Arg	Basic Polar	0.81	Transition
		T	414Cys	Uncharged Polar	0.19
Exon 2	3281	A	457Lys	Basic Polar	0.19	Transition
		G	457Glu	Acidic Polar	0.81
Exon 2	3301	A	463Lys	Basic Polar	0.19	Transversion
		C	463Asn	Uncharged Polar	0.81
Exon 2	3311	C	467Pro	Nonpolar	0.19	Transition
		T	467Ser	Uncharged Polar	0.81
Exon 2	3372	A	487Gln	Uncharged Polar	0.58	Transition
		G	487Arg	Basic Polar	0.42
Intron 2	3404	A	-	-	0.19	Transition
		G			0.81
Exon 3	5108	A	513Lys	Basic Polar	0.11	Transition
		G	513Glu	Acidic Polar	0.89
Exon 3	5111	C	514Pro	Nonpolar	0.82	Transition
		T	514Ser	Uncharged Polar	0.18
Exon 5	7314	A	598Asn	Uncharged Polar	0.87	Transition
		G	598Asp	Acidic Polar	0.13
3' UTR	9994	C	-	-	0.15	Transversion
		G			0.85
3' UTR	9999	A	-	-	0.88	Transversion
		T			0.12
3' UTR	10247	C	-	-	0.31	Transition
		T			0.69
3' UTR	10914	C	-	-	0.38	Transition
		T			0.62
3' UTR	11105	C	-	-	0.88	Transition
		T			0.12
3' UTR	11146	C	-	-	0.35	Transition
		T			0.65
3' UTR	11184	C	-	-	0.35	Transition
		T			0.65
3' UTR	11228	C	-	-	0.83	Transition
		T			0.17

SNPs identified from sequencing RNASEL exons from 13 equine individuals, CHORI BAC 159N12 and the reference transcript sequence. Positions are identified from the genomic consensus sequence submitted to GenBank [GenBank: EF070193].

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ISSN: 1471-2164

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