Figure 3

eLRR protein predicted architectures (part 1). Consensus architectures are shown for all proteins in the LRR_Ig/FN3 group and for all proteins in subfamilies in the LRR_Only group. An additional set of LRR_Only singletons is listed separately in Table 1. Protein names are shown below the corresponding structures (black, mammalian; blue, fly; red, worm). All figures are drawn to scale (see Key). Consensus architectures were derived for single proteins and across subfamilies from convergent evidence from motif and topology prediction programmes. Where there is a range in number of predicted LRRs or other domains across members of a subfamily, this is indicated next to the domain. A range in length of the cytoplasmic domain is similarly indicated, where it exceeds 20 amino acids. Tightly clustered subfamilies (e.g., Slits, Amigos) are listed under a single consensus architecture. Clusters with more structurally diverse proteins are indicated by the brackets; the numbers refer to e-value and inflation parameter at which the proteins cluster in the MCL programme. See Key for more information.