Table 1 Treatment Contrasts

snell5^a

Pit1^dw/dwmales, age 4–6 months, n = 4

Pit1^dw/?control males, age 4–6 months, n = 4

snell25^a

Pit1^dw/dwmales, age 24–26 months, n = 3

Pit1^dw/?control males, age 24–26 months, n = 3

ames5A^b

Prop1^df/dfmales, age 4–6 months, n = 5

Prop1^+/+ control males, age 4–6 months, n = 5

ames13A^b

Prop1^df/dfmales, age 12–14 months, n = 5

Prop1^+/+ control males, age 12–14 months, n = 5

ames25A^b

Prop1^df/dfmales, age 24–27 months, n = 5

Prop1^+/+ control males, age 24–27 months, n = 5

ames3B^c

Prop1^df/dfmales, age 3 months, n = 3

Prop1^+/+ control males, age 3 months, n = 5

ames6B^c

Prop1^df/dfmales, age 6 months, n = 3

Prop1^+/+ control males, age 6 months, n = 5

ames12B^c

Prop1^df/dfmales, age 12 months, n = 3

Prop1^+/+ control males, age 12 months, n = 5

ames24B^c

Prop1^df/dfmales, age 24 months, n = 3

Prop1^+/+ control males, age 24 months, n = 5

little3^c

Ghrhr^lit/litmales, age 3 months, n = 3

Ghrhr^lit/+males, age 3 months, n = 3

little6^c

Ghrhr^lit/litmales, age 6 months, n = 3

Ghrhr^lit/+males, age 6 months, n = 3

little12^c

Ghrhr^lit/litmales, age 12 months, n = 3

Ghrhr^lit/+males, age 12 months, n = 3

little24^c

Ghrhr^lit/litmales, age 24 months, n = 3

Ghrhr^lit/+males, age 24 months, n = 3

GHR-KO^d

GHR(-/-) males, age 42 days, n = 3

wild type males, age 42 days, n = 3

GHR-KI1^d

GHR knock-in mutant 569, males, age 42 days, n = 3

wild type males, age 42 days, n = 3

GHR-KI2^d

GHR knock-in mutant 391, males, age 42 days, n = 3

wild type males, age 42 days, n = 3

B6^e

C57BL/6J (B6) females, age 2 months, n = 3 (20–30% reduced serum IGF-I)

C3H/HeJ (C3H) females, age 2 months, n = 3

Gender^f

wild type females, age 3–6 months, n = 6

wild type males, age 3–6 months, n = 6

cr(2,6)^g

4 months of 30% calorie restriction, initiated age 2, tissue harvest age 6, wild type females, n = 8

wild type littermates of treatment A fed on control diet, n = 7

cr(2,6)df^g

4 months of 30% calorie restriction, initiated age 2, tissue harvest age 6, Prop1^df/dffemales, n = 8

Prop1^df/dffemale littermates of treatment A with control diet, n = 8

cr(20,22)^h

2 months of 40% calorie restriction, initiated age 20, tissue harvest age 22, strain B6C3F1 males, n = 4

strain B6C3F1 males fed on control diet, tissue harvest age 22, n = 4

cr(5,22)^h

17 months 40% calorie restriction, initiated age 5, tissue harvest age 22, strain B6C3F1 males, n = 4

strain B6C3F1 males fed on control diet, tissue harvest age 22, n = 4

met^h

metformin, 2100 mg per kg diet, tissue harvest age 22, strain B6C3F1 males, n = 4

control diet, tissue harvest age 22, strain B6C3F1 males, n = 4

met(db/db)ⁱ

metformin, 400 mg/kg, C57BL/ksj – db/db males, n = 5

placebo, C57BL/ksj – db/db males, n = 5

glip^h

glipizide, 1050 mg per kg diet, tissue harvest age 22, strain B6C3F1 males, n = 4

control diet, tissue harvest age 22, strain B6C3F1 males, n = 4

gm^h

metformin & glipizide, met dose: 1050 mg per kg diet, glip dose: 525 mg per kg diet, tissue harvest age 22, strain B6C3F1 males, n = 4

control diet, tissue harvest age 22, strain B6C3F1 males, n = 4

ros^h

rosiglitazone, 80 mg per kg diet, tissue harvest age 22, strain B6C3F1 males, n = 4

control diet, tissue harvest age 22, strain B6C3F1 males, n = 4

soy^h

soy isoflavone extract, 0.25%, tissue harvest age 22, strain B6C3F1 males, n = 4

control diet, tissue harvest age 22, strain B6C3F1 males, n = 4

lowfat1^j

4.5% fat diet by weight, congenic C57BL/6J males, n = 3

21% fat diet by weight, congenic C57BL/6J males, n = 3

lowfat2^k

very low fat diet, strain C57BL/6J males, n = 5

normal diet, strain C57BL/6J males, n = 5

age^l

age 4 months, wild type, n = 4

age 32 months, wild type, n = 4