Skip to main content

Table 4 Frame disruption placement and alternative splicing

From: Frame disruptions in human mRNA transcripts, and their relationship with splicing and protein structures

Type of initial frame disruption Alignment verification Type of exon *   
   Observed [constitutive : alternative] Expected [constitutive : alternative] Significance
Frameshift All cases 191 : 156 258.8 : 88.2 †††
  Cases with verifying alignments 156 : 125 209.6 : 71.4 †††
Stop codon All cases 33 : 40 54.4 : 18.6 †††
  Cases with verifying alignments 13 : 26 29.1 : 9.9 †††
Frameshift or stop codon All cases 228 : 191 312.5 : 106.5 †††
  Cases with verifying alignments 174 : 151 242.4 : 82.7 †††
  Cases with verifying alignments (without 'probable UTR features') 114 : 95 143.8 : 65.2 †††
  1. * Ratios are for numbers expected or observed in constitutive exons versus alternative ones. Expectations and test are performed as for Table 1.