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Table 4 Genes with down-regulated expression in the heart during iron overload

From: Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse

Gene name Symbol Accession. Fold change
uncoupling protein 1, mitochondrial Ucp1 NM_009463 -4.47 **
actin, alpha 1, skeletal muscle Acta1 NM_009606 -2.79 *
chemokine (C-X-C motif) ligand 7 Cxcl7 NM_023785 -2.41 *
stearoyl-Coenzyme A desaturase 1 Scd1 NM_009127 -2.40 **
heat shock protein 1B Hspa1b NM_010478 -2.25 **
heat shock protein 105 Hsp105 NM_013559 -2.25 **
tubulin, beta 1, 2810484G07Rik Tubb1   -2.15 *
Adipsin Adn NM_013459 -1.92 **
carbonic anhydrase 3 Car3 NM_007606 -1.91 **
DnaJ (Hsp40) homolog, subfamily B, member 1 Dnajb1 NM_018808 -1.90 **
ERBB receptor feedback inhibitor 1 Errfi1 NM_133753 -1.81 **
RIKEN full-length enriched library, clone:F830002E14 product: hypothetical Phenylalanine-rich region profile containing protein   AK089567 -1.69 **
fatty acid synthase Fasn NM_007988 -1.65 **
dickkopf homolog 3 (Xenopus laevis) Dkk3 NM_015814 -1.61 *
Wnt inhibitory factor 1 Wif1 NM_011915 -1.60 **
glycoprotein 5 (platelet) Gp5 NM_008148 -1.57 *
heat shock protein 1, alpha Hspca NM_010480 -1.53 **
  mt-Nd5   -1.52 *
adipocyte, C1Q and collagen domain containing Acdc NM_009605 -1.50 **
3-hydroxybutyrate dehydrogenase (heart, mitochondrial) Bdh NM_175177 -1.50 *
heat shock protein 1, beta Hspcb NM_008302 -1.49 **
4-aminobutyrate aminotransferase Abat NM_172961 -1.49 **
DNA-damage-inducible transcript 4 Ddit4 NM_029083 -1.49 **
cyclin-dependent kinase inhibitor 1A Cdkn1a NM_007669 -1.49 **
heat shock protein 1 Hspb1 NM_013560 -1.48 **
potassium voltage-gated channel, shaker-related subfamily, member 5 Kcna5 NM_145983 -1.46 **
CD9 antigen Cd9 NM_007657 -1.45 *
protein phosphatase 1, regulatory (inhibitor) subunit 3C Ppp1r3c NM_016854 -1.44 **
RIKEN full-length enriched library, clone:2510042H12 product: weakly similar to RAT HEMOGLOBIN ALPHA CHAIN (FRAGMENT) [Rattus norvegicus]   AK011092 -1.44 *
immunoglobulin superfamily, member 1 Igsf1 NM_183336 -1.43 **
SRY-box containing gene 18 Sox18 NM_009236 -1.42 *
phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A Pib5pa NM_172439 -1.41 *
transferrin receptor Tfrc NM_011638 -1.41 **
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1 Chordc1 NM_025844 -1.40 **
eukaryotic translation elongation factor 2 Eef2 NM_007907 -1.40 **
FERM domain containing 5 Frmd5 NM_172673 -1.40 **
inhibitor of DNA binding 1 Idb1 NM_010495 -1.40 **
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide P4ha1 NM_011030 -1.40 **
protein O-fucosyltransferase 2 Pofut2 NM_030262 -1.40 *
1500015O10Rik   NM_024283 -1.40 **
  1. *Data obtained with 2 high-iron and 2 control samples.
  2. ** Data obtained with 3 high-iron and 3 control samples.