Figure 2
From: A distinct epigenetic signature at targets of a leukemia protein
AML1-MTG16-induced downregulation of putative AML1-targets. A. The AML1-consensus motif, containing the AML1-consensus sequence (framed), found by bioinformatic analysis of the genes significantly downregulated in A16 cells. The height of the columns associated with each nucleotide is proportional to the conservation level. The "logo" representation of the motif instead indicates in which proportion the single bases are present at each position. B. Seventeen out of the 37 downregulated genes are putative AML1-targets. The fold-changes of five of the most significantly downregulated genes are reported at right. C. Real time RT-PCR confirmed the significant (p < 0.01) downregulation of the five genes.