Table 2 Selection of genes differentially expressed in AML1-MTG16-positive cells versus AML1-MTG16-negative cells grown in the presence of G-CSF for 16 h.
From: A distinct epigenetic signature at targets of a leukemia protein
Affymetrix ID | NCBI acc. number | Gene Symbol | Gene Title | GO/Iingenuity annotations | Fold change |
|---|---|---|---|---|---|
1437100_x_at | BB206220 | Pim3 | proviral integration site 3 | kinase signaling pathway | 24.5 |
1460300_a_at | NM_008523 | Ltk | leukocyte tyrosine kinase | kinase signaling pathway | 19.9 |
1416257_at | NM_009794 | Capn2 | calpain 2 | proteolysis/cell migration | 17.7 |
1417314_at | NM_008198 | H2-Bf | histocompatibility 2, complement component factor B | cell proliferation/complement activation | 14.7 |
1425380_at | AF331457 | Rasgrp4 | RAS guanyl releasing protein 4 | intracellular signaling cascade | 10.4 |
1450322_s_at | NM_011409 | Slfn3 | schlafen 3 | cell proliferation | 10.2 |
1421793_at | NM_010198 | Fgf11 | fibroblast growth factor 11 | signal transduction/cell proliferation | 9.5 |
1420348_at | NM_008499 | Lhx5 | LIM homeobox protein 5 | regulation of transcription | 8.8 |
1419605_at | NM_010796 | Mgl1 | macrophage galactose N-acetyl-galactosamine specific lectin 1 | cell adhesion | 8.6 |
1420360_at | NM_010051 | Dkk1 | dickkopf homolog 1 (Xenopus laevis) | signal transduction/apoptosis | 6.7 |
1425647_at | BG069740 | Rnf33 | ring finger protein 33 | --- | 6.4 |
1434851_s_at | AU015319 | Crb3 | crumbs homolog 3 (Drosophila) | intercellular junction assembly | 6.1 |
1427102_at | AF099975 | Slfn4 | schlafen 4 | cell proliferation | 5.9 |
1437218_at | BM234360 | Fn1 | fibronectin 1 | cell adhesion | 5.5 |
1417777_at | BC014865 | Ltb4dh | leukotriene B4 12-hydroxydehydrogenase | metabolism | 5.5 |
1419406_a_at | NM_016707 | Bcl11a | B-cell CLL/lymphoma 11A (zinc finger protein) | T/B-cell differentiation/corepressor | 5.5 |
1418358_at | NM_008574 | Mcsp | mitochondrial capsule selenoprotein | sperm motility | 5.4 |
1450499_at | NM_009124 | Sca1 | spinocerebellar ataxia 1 homolog (human) | --- | 5.2 |
1418257_at | BB732135 | Slc12a7 | solute carrier family 12, member 7 | ion transport | 5.1 |
1424744_at | BC021950 | Sds | serine dehydratase | amino acid metabolism | 5.1 |
1456305_x_at | BB702568 | Obox1 | oocyte specific homeobox 1 | regulation of transcription | 5.0 |
1449707_at | C80272 | Nr5a2 | nuclear receptor subfamily 5, group A, member 2 | regulation of transcription | 4.9 |
1421504_at | NM_009239 | Sp4 | trans-acting transcription factor 4 | regulation of transcription | 4.8 |
1427079_at | U51204 | Mapre3 | microtubule-associated protein, RP/EB family, member 3 | cytoskeleton organization | 4.8 |
1429626_at | AV024301 | Sftpa | surfactant associated protein A | cell adhesion | 4.8 |
1452793_at | AI509011 | Cldn10 | claudin 10 | cell adhesion | 4.7 |
1419507_at | NM_013713 | Krtap15 | keratin associated protein 15 | --- | 4.7 |
1421375_a_at | NM_011313 | S100a6 | S100 calcium binding protein A6 (calcyclin) | cell proliferation | 4.5 |
1419517_at | NM_028408 | 2900075G08Rik | RIKEN cDNA 2900075G08 gene | intracellular signaling cascade | 4.4 |
1454736_at | BM119297 | 4921515A04Rik | RIKEN cDNA 4921515A04 gene | regulation of transcription | 4.3 |
1436244_a_at | AU067681 | Tle2 | transducin-like enhancer of split 2, homolog of Drosophila E(spl) | regulation of transcription/signal transduction | 4.2 |
1420594_at | NM_007525 | Bard1 | BRCA1 associated RING domain 1 | DNA repair/regulation of transcription/apoptosis | 4.2 |
1426093_at | AF220141 | Trim34 | tripartite motif protein 34 | --- | 4.2 |
1424748_at | BC021504 | Galnt11 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 | metabolism | 4.1 |
1416855_at | BB550400 | Gas1 | growth arrest specific 1 | cell cycle arrest///programmed cell death | 4.0 |
1422310_at | NM_009223 | Snn | stannin | --- | 4.0 |
1452463_x_at | BG966217 | Igk-V8 | immunoglobulin kappa chain variable 8 (V8) | immune response | 4.0 |
1450415_at | NM_008805 | Pde6a | phosphodiesterase 6A, cGMP-specific, rod, alpha | signal transduction | 3.9 |
1418792_at | AF326561 | Sh3gl2 | SH3-domain GRB2-like 2 | --- | 3.9 |
1451759_at | BC013893 | Masp2 | mannan-binding lectin serine protease 2 | cell adhesion/complement activation | 3.9 |
1418921_at | AY059393 | Necl1-pending | nectin-lke 1 | cell adhesion | 3.9 |
1416188_at | BC004651 | Gm2a | GM2 ganglioside activator protein | sphingolipid metabolism | 3.8 |
1448392_at | NM_009242 | Sparc | secreted acidic cysteine rich glycoprotein | cell proliferation | 3.8 |
1419485_at | BB759833 | Foxc1 | forkhead box C1 | regulation of transcription | 3.7 |
1419602_at | NM_010451 | Hoxa2 | homeo box A2 | regulation of transcription | 3.7 |
1427358_a_at | BC026671 | Dapk1 | death associated protein kinase 1 | apoptosis | 3.6 |
1450827_at | NM_024245 | Kif23 | kinesin family member 23 | mitosis | 3.6 |
1421280_at | Z36357 | Gabra1 | gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 1 | synaptic transmission | 3.5 |
1452279_at | BB800282 | Pfc | properdin factor, complement | complement activation | 3.5 |
1415854_at | BB815530 | Kitl | kit ligand | cell proliferation/cell adhesion | 3.4 |
1417513_at | AI255184 | Evi5 | ecotropic viral integration site 5 | --- | 3.3 |
1431379_a_at | AK005153 | Slc13a1 | solute carrier family 13 (sodium/sulphate symporters), member 1 | ion transport | 3.2 |
1418476_at | NM_018827 | Crlf1 | cytokine receptor-like factor 1 | --- | 3.2 |
1416009_at | NM_019793 | Tm4sf8-pending | transmembrane 4 superfamily member 8 | signal transduction/cell proliferation | 3.1 |
1451633_a_at | BC025929 | Gng1 | guanine nucleotide binding protein (G protein), gamma 1 subunit | G-protein signaling pathway | -3.0 |
1425978_at | AF384055 | Srfcp-pending | SRF co-factor protein (cardiac and smooth muscle) | regulation of transcription/positive regulation of cell proliferation | -3.0 |
1425153_at | BC008538 | Myh2 | myosin, heavy polypeptide 2, skeletal muscle, adult | cytoskeleton organization | -3.1 |
1448755_at | AF011450 | Col15a1 | procollagen, type XV | cell adhesion | -3.2 |
1433888_at | AV343478 | Atp2b2 | ATPase, Ca++ transporting, plasma membrane 2 | metabolism | -3.5 |
1426868_x_at | AK003174 | Lmna | lamin A | cell morphology | -3.5 |
1423292_a_at | BG072867 | Prx | periaxin | intracellular signaling cascade | -3.6 |
1449891_a_at | NM_028523 | Esdn-pending | endothelial and smooth muscle cell-derived neuropilin-like molecule | --- | -3.6 |
1425708_at | AF285585 | Rnf17 | ring finger protein 17 | --- | -4.2 |
1449836_x_at | NM_007546 | Biklk | Bcl2-interacting killer-like | apoptosis | -4.6 |
1448710_at | D87747 | Cxcr4 | chemokine (C-X-C motif) receptor 4 | defense response/hematopoiesis | -4.8 |
1419227_at | NM_009839 | Cct6b | chaperonin subunit 6b (zeta) | protein folding | -5.0 |
1455853_x_at | BB768303 | 2700085A14Rik (Sas) | RIKEN cDNA 2700085A14 gene (Sarcoma amplified sequence) | cell proliferation/signal transduction | -5.3 |
1416822_at | BC013711 | Es2el | expressed sequence 2 embryonic lethal | --- | -5.4 |
1422473_at | BM246564 | Pde4b | phosphodiesterase 4B, cAMP specific | signal transduction | -7.8 |
1418499_a_at | NM_020574 | Kcne3 | potassium voltage-gated channel, Isk-related subfamily, gene 3 | ion transport | -8.3 |
1419537_at | NM_031198 | Tcfec | transcription factor EC | regulation of transcription | -20.6 |
1449347_a_at | NM_021365 | Xlr4 | X-linked lymphocyte-regulated 4 | chromatin remodeling? | -34.4 |