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Table 1 Dose response genes identified using SAM software.

From: Genes involved in TGFβ1-driven epithelial-mesenchymal transition of renal epithelial cells are topologically related in the human interactome map

GB accession ID EntrezGene ID Gene Symbol Description Score(d) R^2
NM_003246 7057 THBS1 thrombospondin 1 2,75 0.89
NM_005630 6578 SLCO2A1 solute carrier organic anion transporter family, member 2A1 2,64 0.77
X62048 7465 WEE1 WEE1 homolog (S. pombe) 2,56 0.64
AY033606 57120 GOPC golgi associated PDZ and coiled-coil motif containing 2,54 0.72
NM_014187 29100 HSPC171 HSPC171 protein 2,47 0.96
NM_002709 5500 PPP1CB protein phosphatase 1, catalytic subunit, beta isoform 2,44 0.84
NM_005032 5358 PLS3 plastin 3 (T isoform) 2,36 0.58
NM_021977 6581 SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3 2,36 0.99
AF220030 117854 TRIM6 tripartite motif-containing 6 2,33 0.76
NM_018695 55914 ERBB2IP Erbb2 interacting protein 2,31 0.72
NM_004735 9208 LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 2,27 0.83
NM_018561 25862 USP49 ubiquitin specific peptidase 49 2,25 0.74
NM_032812 84898 PLXDC2 plexin domain containing 2 2,20 0.92
NM_004718 9167 COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 2,20 0.84
NM_016651 51339 DACT1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) 2,20 0.97
AK056277 152048 FLJ31715 hypothetical protein FLJ31715 2,20 0.67
NM_004643 8106 PABPN1 poly(A) binding protein, nuclear 1 2,18 0.64
NM_000876 3482 IGF2R insulin-like growth factor 2 receptor 2,17 0.97
AF326917 26053 AUTS2 autism susceptibility candidate 2 2,16 0.64
NM_003685 8570 KHSRP KH-type splicing regulatory protein (FUSE binding protein 2) 2,14 0.52
NM_001300 1316 KLF6 Kruppel-like factor 6 2,12 0.81
NM_022823 64838 FNDC4 fibronectin type III domain containing 4 2,12 0.70
NM_004663 8766 RAB11A RAB11A, member RAS oncogene family 2,10 0.97
NM_002210 3685 ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 2,08 0.62
BC018067 9364 RAB28 RAB28, member RAS oncogene family 2,05 0.92
NM_021738 6840 SVIL supervillin -2,65 0.68
AB028981 23348 DOCK9 dedicator of cytokinesis 9 -2,40 0.67
NM_002993 6372 CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) -2,37 0.21
NM_002371 4118 MAL mal, T-cell differentiation protein -2,30 0.56
AF402776 114614 BIC BIC transcript -2,30 0.41
  1. The expression of these transcripts depends on the TGFβ1 concentration used. The first 25 genes are directly related to the TGFβ1 dosage (d value higher than zero), the last five are inversely related (d value lower than zero). Columns show: the GenBank accession number, the EntrezGene ID, the Gene symbol, the gene's description, the "d score" calculated by the SAM software, and the correlation coefficient R2.