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Table 1 Dose response genes identified using SAM software.

From: Genes involved in TGFβ1-driven epithelial-mesenchymal transition of renal epithelial cells are topologically related in the human interactome map

GB accession ID

EntrezGene ID

Gene Symbol

Description

Score(d)

R^2

NM_003246

7057

THBS1

thrombospondin 1

2,75

0.89

NM_005630

6578

SLCO2A1

solute carrier organic anion transporter family, member 2A1

2,64

0.77

X62048

7465

WEE1

WEE1 homolog (S. pombe)

2,56

0.64

AY033606

57120

GOPC

golgi associated PDZ and coiled-coil motif containing

2,54

0.72

NM_014187

29100

HSPC171

HSPC171 protein

2,47

0.96

NM_002709

5500

PPP1CB

protein phosphatase 1, catalytic subunit, beta isoform

2,44

0.84

NM_005032

5358

PLS3

plastin 3 (T isoform)

2,36

0.58

NM_021977

6581

SLC22A3

solute carrier family 22 (extraneuronal monoamine transporter), member 3

2,36

0.99

AF220030

117854

TRIM6

tripartite motif-containing 6

2,33

0.76

NM_018695

55914

ERBB2IP

Erbb2 interacting protein

2,31

0.72

NM_004735

9208

LRRFIP1

leucine rich repeat (in FLII) interacting protein 1

2,27

0.83

NM_018561

25862

USP49

ubiquitin specific peptidase 49

2,25

0.74

NM_032812

84898

PLXDC2

plexin domain containing 2

2,20

0.92

NM_004718

9167

COX7A2L

cytochrome c oxidase subunit VIIa polypeptide 2 like

2,20

0.84

NM_016651

51339

DACT1

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

2,20

0.97

AK056277

152048

FLJ31715

hypothetical protein FLJ31715

2,20

0.67

NM_004643

8106

PABPN1

poly(A) binding protein, nuclear 1

2,18

0.64

NM_000876

3482

IGF2R

insulin-like growth factor 2 receptor

2,17

0.97

AF326917

26053

AUTS2

autism susceptibility candidate 2

2,16

0.64

NM_003685

8570

KHSRP

KH-type splicing regulatory protein (FUSE binding protein 2)

2,14

0.52

NM_001300

1316

KLF6

Kruppel-like factor 6

2,12

0.81

NM_022823

64838

FNDC4

fibronectin type III domain containing 4

2,12

0.70

NM_004663

8766

RAB11A

RAB11A, member RAS oncogene family

2,10

0.97

NM_002210

3685

ITGAV

integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)

2,08

0.62

BC018067

9364

RAB28

RAB28, member RAS oncogene family

2,05

0.92

NM_021738

6840

SVIL

supervillin

-2,65

0.68

AB028981

23348

DOCK9

dedicator of cytokinesis 9

-2,40

0.67

NM_002993

6372

CXCL6

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

-2,37

0.21

NM_002371

4118

MAL

mal, T-cell differentiation protein

-2,30

0.56

AF402776

114614

BIC

BIC transcript

-2,30

0.41

  1. The expression of these transcripts depends on the TGFβ1 concentration used. The first 25 genes are directly related to the TGFβ1 dosage (d value higher than zero), the last five are inversely related (d value lower than zero). Columns show: the GenBank accession number, the EntrezGene ID, the Gene symbol, the gene's description, the "d score" calculated by the SAM software, and the correlation coefficient R2.
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BMC Genomics

ISSN: 1471-2164

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