Table 2 Biological process GO categories with the lowest mean BMD in zebrafish exposed to EE2
From: BMDExpress: a software tool for the benchmark dose analyses of genomic data
Biological Process GO Categorya | Total Genes in Category | Genes with BMD | Mean BMD (ng/L) | Std Dev BMD | Mean BMDL (ng/L) | Minimum BMD (ng/L) | Upregulated/Downregulated Probes |
|---|---|---|---|---|---|---|---|
24 h | |||||||
Protein amino acid glycosylation | 24 | 4 | 10.88 | 1.80 | 7.56 | 9.47 | 4/0 |
Cell migration involved in gastrulation | 28 | 3 | 12.07 | 0.82 | 8.24 | 11.46 | 0/3 |
Monocarboxylic acid metabolic process | 28 | 3 | 12.30 | 5.79 | 8.15 | 7.90 | 5/0 |
tRNA aminoacylation | 25 | 13 | 12.56 | 6.62 | 8.78 | 5.74 | 18/0 |
Nitrogen compound catabolic process | 11 | 3 | 12.57 | 1.11 | 8.53 | 11.75 | 0/3 |
Regulation of apoptosis | 45 | 3 | 12.76 | 2.59 | 8.59 | 11.24 | 2/1 |
Amino acid and derivative metabolic process | 83 | 27 | 12.94 | 4.82 | 8.82 | 5.74 | 22/12 |
Amino acid metabolic process | 72 | 26 | 12.99 | 4.91 | 8.85 | 5.74 | 22/11 |
Amino acid biosynthetic process | 18 | 5 | 13.05 | 3.54 | 8.70 | 7.90 | 4/2 |
Amine metabolic process | 99 | 30 | 13.07 | 4.63 | 8.88 | 5.74 | 24/14 |
168 h | |||||||
Lipid transport | 10 | 3 | 11.57 | 2.54 | 8.60 | 8.64 | 1/3 |
Response to external stimulus | 41 | 3 | 15.99 | 7.96 | 8.12 | 10.75 | 0/3 |
Glycolysis | 33 | 6 | 19.75 | 10.52 | 13.14 | 9.27 | 2/5 |
Carbohydrate catabolic process | 44 | 7 | 20.71 | 9.93 | 17.79 | 9.27 | 3/5 |
Alcohol metabolic process | 61 | 10 | 21.39 | 12.25 | 13.14 | 9.27 | 3/8 |
Cellular macromolecule catabolic process | 79 | 8 | 23.02 | 11.28 | 18.80 | 9.27 | 4/5 |
Protein-DNA complex assembly | 30 | 3 | 23.15 | 16.13 | 9.61 | 12.85 | 1/2 |
Monosaccharide metabolic process | 48 | 7 | 23.22 | 13.28 | 17.79 | 9.27 | 3/5 |
Cellular protein complex assembly | 9 | 3 | 23.87 | 15.67 | 11.39 | 10.66 | 1/2 |
Protein import | 17 | 3 | 23.87 | 15.67 | 11.39 | 10.66 | 1/2 |