Table 2 Selected top-ranked candidate genes for FAS identified using binary matrix filtering

1

17/29

FGFR1 ¹

Fibroblast growth factor receptor 1

8p11.2

Involved in limb induction, play a role in bone elongation modulation

2

16/29

MSX1 ²

Msh homeobox homolog 1 gene

4p16.3-p16.1

Potential repressor function in cell cycle progression, transcription repressor

3

15/29

FGFR2 ¹

Fibroblast growth factor receptor 2

10q26

Involved in vertebral development, important regulator of bone formation and osteoblast activity

4

15/29

FOXG1B

Forkhead box G1B

14q13

Embryonic transcriptional regulator, playing a critical role in brain development

5

15/29

HOXA1

Homeobox A1

7p15.3

Involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development

6

14/29

BMP4 ^2,3

Bone morphogenetic protein 4

14q22-q23

Regulating myogenesis through dosage-dependent PAX3 expression in pre-myogenic cells, inducing apoptosis and chondrogenesis in the chick limb bud

7

14/29

FGFR3 ¹

Fibroblast growth factor receptor 3

4p16.3

Negative regulator of bone growth promotion, inhibition of chondrocyte proliferation and differentiation depending on devlopmental time

8

14/29

GNAS ²

Gnas complex locus

20q13.2-q13.3

Involved as modulators or transducers in various transmembrane signaling systems primarily mediating the differential effects of parathyroid hormone

9

14/29

PAX6

Paired box gene 6

11p13

Key regulator of eye, pancreas, central nervous system development and regulator of glial precursors in the ventral neural tube