Table 8 Predicted ISRE target genes in the specific response to LPS and PIC
From: Functional genomic delineation of TLR-induced transcriptional networks
Symbol | ISRE BS (location) | LPS maximum induction (log2) | LPS kinetics | Validated BS | ||||
|---|---|---|---|---|---|---|---|---|
| Â | Human | Mouse | MmBMM | MmRAW | HsM1 | HsM2 | Â | Â |
IFNB1 | GGGAGAAGTGAAAGT (-59) | GGGAGAACTGAAAGT (-150) | 5.53 | 0.44 | 3.28 | x | ED/DD** | [2] |
TOR3A | GCGGTTTCATTTCCC (161) | ACTGTTTCATTTTCC (-485) | 4.08 | 2.31 | x | -0.19 | DD | [48] |
OAS3 | GAAAGAAACGAAACT (-29,108) | GGAGAAAACGAAAGT (-77,0) | 5.21 | 2.85 | x | 2.42 | DD | [49, 50] |
OAS2 | TCAGTTTCAGTTTCC (49) | TGAGTTTCGATTTCC (-74) | 3.24 | 2.1 | 2.56 | 2.53 | DD | [50] |
OASL | TTGAGAATCGAAACT (-288) | CACAAAAGAGAAACT (-159) | 7.93 | 5.79 | 2.7 | 3.98 | ED/DD** | [50] |
CFB (BF) | CTTGTTTCACTTTCA (-98) | ATAGTTTCTGTTTCC (-148) | 8.38 | 3.32 | 2.04 | x | DD | [51] |
TRIM21 | GCGGAAACTGAAAGT (9) | GAGGAAACTGAAAGT (-30,4) | 2.65 | 1.52 | 2.73 | 0.22 | DD | [52] |
IFIH1 | ATCGAAACAGAAACC (-178) | ATCGAAACAGAAACC (-65) | 4.55 | 2.92 | x | 3.09 | DD/ED* | --- |
NMI | N/F | ACCGAAAGTGAAAGT (71) | 3.31 | 1.54 | 1.61 | 1.36 | DD | --- |
LGP2 | TCAGTTTCAGTTTCC (-1) | TCAGTTTCATTTCTA (-1) | 1.87 | 2.07 | x | x | DD | --- |
RTP4 (IFRG28) | ACAGAAACAGAAACT (-39,-15) | TTGGAAACCGAAACT (-84,-58,-35) | 2.65 | 1.59 | x | 2.33 | DD | --- |
BATF2 | GGAGAAACTGAAACT (-2) | GGAGAAACTGAAACT (-95) | 5.64 | 1.9 | x | x | DD | --- |
STAT2 | CTAGTTTCGGTTCCG (-353) | CTGGTTTCAGTTTCC (-303) | 5.94 | 2.01 | 1.5 | 1.5 | DD | --- |