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Table 8 Predicted ISRE target genes in the specific response to LPS and PIC

From: Functional genomic delineation of TLR-induced transcriptional networks

Symbol ISRE BS (location) LPS maximum induction (log2) LPS kinetics Validated BS
  Human Mouse MmBMM MmRAW HsM1 HsM2   
IFNB1 GGGAGAAGTGAAAGT (-59) GGGAGAACTGAAAGT (-150) 5.53 0.44 3.28 x ED/DD** [2]
TOR3A GCGGTTTCATTTCCC (161) ACTGTTTCATTTTCC (-485) 4.08 2.31 x -0.19 DD [48]
OAS3 GAAAGAAACGAAACT (-29,108) GGAGAAAACGAAAGT (-77,0) 5.21 2.85 x 2.42 DD [49, 50]
OAS2 TCAGTTTCAGTTTCC (49) TGAGTTTCGATTTCC (-74) 3.24 2.1 2.56 2.53 DD [50]
OASL TTGAGAATCGAAACT (-288) CACAAAAGAGAAACT (-159) 7.93 5.79 2.7 3.98 ED/DD** [50]
CFB (BF) CTTGTTTCACTTTCA (-98) ATAGTTTCTGTTTCC (-148) 8.38 3.32 2.04 x DD [51]
TRIM21 GCGGAAACTGAAAGT (9) GAGGAAACTGAAAGT (-30,4) 2.65 1.52 2.73 0.22 DD [52]
IFIH1 ATCGAAACAGAAACC (-178) ATCGAAACAGAAACC (-65) 4.55 2.92 x 3.09 DD/ED* ---
NMI N/F ACCGAAAGTGAAAGT (71) 3.31 1.54 1.61 1.36 DD ---
LGP2 TCAGTTTCAGTTTCC (-1) TCAGTTTCATTTCTA (-1) 1.87 2.07 x x DD ---
RTP4 (IFRG28) ACAGAAACAGAAACT (-39,-15) TTGGAAACCGAAACT (-84,-58,-35) 2.65 1.59 x 2.33 DD ---
BATF2 GGAGAAACTGAAACT (-2) GGAGAAACTGAAACT (-95) 5.64 1.9 x x DD ---
STAT2 CTAGTTTCGGTTCCG (-353) CTGGTTTCAGTTTCC (-303) 5.94 2.01 1.5 1.5 DD ---
  1. See legend of Table 7.